Tenm4 - teneurin transmembrane protein 4 Gene

Mus musculus

Also known as Doc4; ELM2; Odz4; l7Rn3; Ten-m4; l(7)-3Rn; mKIAA1302

Gene ID: 23966 | Gene type: protein coding

About Tenm4

Summary

Enables protein homodimerization activity. Involved in central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in cytoplasm; neuron projection; and nucleus. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; forelimb bud; future brain; and somite. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Tenm4 Products(3)

mRNA	Protein	Name
NM_001310760.1	NP_001297689.1	teneurin-4 isoform 1
NM_001310762.1	NP_001297691.1	teneurin-4 isoform 3
NM_011858.4	NP_035988.2	teneurin-4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12000766	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12000766	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac cell fate specification	IMP IMP: Inferred from mutant phenotype	17350578	MGI
acts upstream of or within cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17350578	MGI
involved in central nervous system myelin formation	IMP IMP: Inferred from mutant phenotype	22915103	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	15489520	MGI
involved in positive regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	15489520	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	22915103	MGI
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22915103	MGI
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	35484136	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22915103	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	35484136	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	22915103	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22915103	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9649432	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

teneurin-4

downstream of CHOP4	odd Oz/ten-m homolog 4
protein Odd Oz/ten-m homolog 4	ten-4
tenascin-M4

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14365	TENM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22855	Tenm4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tenm4	NCBI	NCBI:26011

Name
Email *

	Sorry, but the email address you supplied was invalid.