Ets1 - E26 avian leukemia oncogene 1, 5' domain Gene

Mus musculus

Also known as vs; p54; Tpl1; Ets-1; D230050P06

Gene ID: 23871 | Gene type: protein coding

About Ets1

Summary

Enables DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Ets1 Products(6)

mRNA	Protein	Name
NM_001038642.2	NP_001033731.1	protein C-ets-1 isoform 2
NM_001372534.1	NP_001359463.1	protein C-ets-1 isoform 3
NM_001372535.1	NP_001359464.1	protein C-ets-1 isoform 4
NM_001372536.1	NP_001359465.1	protein C-ets-1 isoform 5
NM_001372537.1	NP_001359466.1	protein C-ets-1 isoform 6
NM_011808.3	NP_035938.2	protein C-ets-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7774816	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12119294	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9199349	MGI
enables nucleic acid binding	EXP EXP: Inferred from Experiment	15994560	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7774816	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1409581	MGI
enables sequence-specific double-stranded DNA binding	IMP IMP: Inferred from mutant phenotype	15994560	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22294049	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12464608	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12119294	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12464608	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15541767	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12119294	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12464608	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein C-ets-1

avian erythroblastosis virus E26 oncogene 1

tumor progression locus 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04562	ETS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16879	Ets1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23321	Ets1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ets1	NCBI	NCBI:2113

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