2. Gene
  3. Leo1 - Leo1, Paf1/RNA polymerase II complex component Gene

Leo1 - Leo1, Paf1/RNA polymerase II complex component Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gm185

Gene ID: 235497 | Gene type: protein coding

About Leo1

Summary

Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in endodermal cell fate commitment and stem cell population maintenance. Predicted to be located in centrosome; fibrillar center; and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in brain; gonad; heart; and medial-nasal process mesenchyme. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]

Leo1 Products(1)

mRNA Protein Name
NM_001039522.1 NP_001034611.1 RNA polymerase-associated protein LEO1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
contributes to protein binding IPI
IPI: Inferred from physical interaction
27749823 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22252316 MGI
Biological Process GO Annotation Evidence Reference Source
involved in endodermal cell fate commitment IMP
IMP: Inferred from mutant phenotype
19345177 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19345177 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA polymerase-associated protein LEO1

Leo1, Paf1/RNA polymerase II complex component, homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07592 LEO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22216 Leo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28738 Leo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Leo1 NCBI NCBI:123169