Cplx3 - complexin 3 Gene

Mus musculus

Also known as ERGL; CpxIII; Lamn1l; Lman1l; ERGIC-53L

Gene ID: 235415 | Gene type: protein coding

About Cplx3

Summary

Enables SNARE binding activity and neurotransmitter transmembrane transporter activity. Involved in Insulin secretion; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle exocytosis. Acts upstream of or within regulation of neurotransmitter secretion. Located in cytosol; photoreceptor ribbon synapse; and plasma membrane. Is anchored component of presynaptic active zone membrane and anchored component of synaptic vesicle membrane. Is expressed in cerebral cortex and cortical layer V. Orthologous to human CPLX3 (complexin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cplx3 Products(1)

mRNA	Protein	Name
NM_146223.3	NP_666335.1	complexin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	15911881	MGI
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15911881	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in insulin secretion	IMP IMP: Inferred from mutant phenotype	15911881	MGI
acts upstream of or within regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	15911881	MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA IDA: Inferred from direct assay	27239031	MGI
involved in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	27239031	MGI
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	15911881	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	15911881	MGI
located in membrane	IDA IDA: Inferred from direct assay	15911881	MGI
NOT located in nucleus	IDA IDA: Inferred from direct assay	15911881	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	27239031	MGI
is active in photoreceptor ribbon synapse	IMP IMP: Inferred from mutant phenotype	27239031	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15911881	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	15911881	MGI
is active in presynaptic active zone membrane	IEP IEP: Inferred from expression pattern	15911881	MGI
is active in presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	15911881	MGI
located in synapse	IDA IDA: Inferred from direct assay	15911881	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	15911881	MGI
is active in synaptic vesicle membrane	IEP IEP: Inferred from expression pattern	15911881	MGI
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	15911881	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

complexin-3

CPX III	complexin III
lectin, mannose-binding, 1 like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03099	CPLX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20003	Cplx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26506	Cplx3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cplx3	NCBI	NCBI:594855

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