2. Gene
  3. Spg7 - SPG7, paraplegin matrix AAA peptidase subunit Gene

Spg7 - SPG7, paraplegin matrix AAA peptidase subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PGN; Cmar

Gene ID: 234847 | Gene type: protein coding

About Spg7

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptidase activity. Acts upstream of or within anterograde axonal transport and mitochondrion organization. Located in mitochondrial inner membrane. Part of m-AAA complex. Is expressed in central nervous system; olfactory epithelium; and retina nuclear layer. Used to study hereditary spastic paraplegia 7. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin). [provided by Alliance of Genome Resources, Apr 2022]

Spg7 Products(2)

mRNA Protein Name
NM_001364435.1 NP_001351364.1 paraplegin isoform 2 precursor
NM_153176.5 NP_694816.3 paraplegin isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19656850 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
14722615 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
14722615 MGI
Cellular Component GO Annotation Evidence Reference Source
part of m-AAA complex IDA
IDA: Inferred from direct assay
19656850 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19656850 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14722615 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paraplegin

cell matrix adhesion regulator

spastic paraplegia 7 homolog

spastic paraplegia 7 protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13663 SPG7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21436 Spg7 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spg7 NCBI NCBI:6687