2. Gene
  3. Aimp2 - aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Gene

Aimp2 - aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jtv1; Aimp2(p38)

Gene ID: 231872 | Gene type: protein coding

About Aimp2

Summary

Enables molecular adaptor activity. Involved in positive regulation of aminoacyl-tRNA Ligase activity and protein-containing complex assembly. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of protein ubiquitination; and type II pneumocyte differentiation. Located in nucleus. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including olfactory epithelium; orbito-sphenoid; submandibular gland primordium; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Aimp2 Products(2)

mRNA Protein Name
NM_001172146.1 NP_001165617.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1
NM_146165.2 NP_666277.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular adaptor activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12060739 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12819782 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
12819782 MGI
acts upstream of protein ubiquitination IDA
IDA: Inferred from direct assay
12819782 MGI
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
12060739 MGI
acts upstream of or within type II pneumocyte differentiation IMP
IMP: Inferred from mutant phenotype
12819782 MGI
Cellular Component GO Annotation Evidence Reference Source
part of aminoacyl-tRNA synthetase multienzyme complex IMP
IMP: Inferred from mutant phenotype
12060739 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12819782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 2

ARS interacting multifunctional protein 2

multisynthase complex auxiliary component p38

multisynthetase complex auxiliary component p38

protein JTV-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136431 BC-DXI-843 Inhibitor 99.76% Unkown
HY-150719 AIMP2-DX2-IN-1 ≥98.0% Unkown
HY-RS00498 AIMP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20364 Aimp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26873 Aimp2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aimp2 NCBI NCBI:7965