Sesn2 - sestrin 2 Gene

Mus musculus

Also known as HI95; Ses2; SEST2

Gene ID: 230784 | Gene type: protein coding

About Sesn2

Summary

Enables GDP-dissociation inhibitor activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including positive regulation of lipophagy; protein kinase B signaling; and regulation of cAMP-dependent protein kinase activity. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sesn2 Products(1)

mRNA	Protein	Name
NM_144907.1	NP_659156.1	sestrin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	25259925	MGI
enables PH domain binding	IPI IPI: Inferred from physical interaction	31915252	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18692468	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within D-glucose import	IMP IMP: Inferred from mutant phenotype	22958918	MGI
involved in DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	18692468	MGI
acts upstream of or within activation of protein kinase activity	IDA IDA: Inferred from direct assay	31915252	MGI
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	25259925	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	23274085	MGI
acts upstream of or within fatty acid beta-oxidation	IGI IGI: Inferred from genetic interaction	22958918	MGI
acts upstream of or within glucose homeostasis	IGI IGI: Inferred from genetic interaction	22958918	MGI
acts upstream of or within mitochondrial DNA metabolic process	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	22958918	MGI
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	24947615	MGI
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	20203043	MGI
involved in negative regulation of translation in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	24947615	MGI
acts upstream of or within positive regulation of lipophagy	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within regulation of cAMP-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within response to glucose	IGI IGI: Inferred from genetic interaction	22958918	MGI
acts upstream of or within response to glucose	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within response to insulin	IGI IGI: Inferred from genetic interaction	22958918	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	22958918	MGI
acts upstream of or within triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	22958918	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of TORC2 complex	IDA IDA: Inferred from direct assay	25377878	MGI
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	18692468	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sestrin-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12735	SESN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20488	Sesn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26996	Sesn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sesn2	NCBI	NCBI:83667

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