Aldob - aldolase B, fructose-bisphosphate Gene

Mus musculus

Also known as Aldo2; Aldo-2

Gene ID: 230163 | Gene type: protein coding

About Aldob

Summary

This gene encodes a subunit of the homotetrameric enzyme aldolase B, an isozyme of the class I fructose 1,6-bisphosphate aldolase enzyme. This enzyme catalyzes the conversion of fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Homozygous knockout mice for this gene exhibit liver damage and death following fructose ingestion. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]

Aldob Products(1)

mRNA	Protein	Name
NM_144903.3	NP_659152.1	fructose-bisphosphate aldolase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fructose-1-phosphate aldolase activity	IMP IMP: Inferred from mutant phenotype	25637246	MGI
enables fructose-bisphosphate aldolase activity	IDA IDA: Inferred from direct assay	604178	MGI
enables fructose-bisphosphate aldolase activity	IMP IMP: Inferred from mutant phenotype	25637246	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fructose catabolic process	IDA IDA: Inferred from direct assay	4343087	MGI
involved in fructose catabolic process	IMP IMP: Inferred from mutant phenotype	29533924	MGI
involved in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IMP IMP: Inferred from mutant phenotype	29533924	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	32733884	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fructose-bisphosphate aldolase B

liver-type aldolase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00584	ALDOB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17969	Aldob Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24440	Aldob Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldob	NCBI	NCBI:229

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