Gba2 - glucosidase beta 2 Gene

Mus musculus

Also known as F630034E04

Gene ID: 230101 | Gene type: protein coding

About Gba2

Summary

Enables glucosylceramidase activity; glucosyltransferase activity; and steryl-beta-glucosidase activity. Involved in several processes, including glucosylceramide catabolic process; lipid glycosylation; and regulation of protein polymerization. Located in cytosol. Is extrinsic component of Golgi membrane and extrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and neural retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Gba2 Products(1)

mRNA	Protein	Name
NM_172692.3	NP_766280.2	non-lysosomal glucosylceramidase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-glucosidase activity	IDA IDA: Inferred from direct assay	22659419	MGI
enables beta-glucosidase activity	IMP IMP: Inferred from mutant phenotype	22659419	MGI
enables glucosylceramidase activity	IDA IDA: Inferred from direct assay	17080196	MGI
enables glucosylceramidase activity	IMP IMP: Inferred from mutant phenotype	22659419	MGI
enables glucosyltransferase activity	IDA IDA: Inferred from direct assay	17080196	MGI
enables steryl-beta-glucosidase activity	IDA IDA: Inferred from direct assay	26724485	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	17080196	MGI
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	26724485	MGI
involved in glucosylceramide catabolic process	IDA IDA: Inferred from direct assay	23250757	MGI
involved in glucosylceramide catabolic process	IMP IMP: Inferred from mutant phenotype	17080196	MGI
involved in lipid glycosylation	IDA IDA: Inferred from direct assay	26724485	MGI
involved in regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	25803043	MGI
involved in regulation of membrane lipid distribution	IMP IMP: Inferred from mutant phenotype	25803043	MGI
involved in regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	25803043	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	23250757	MGI
located in cytosol	IDA IDA: Inferred from direct assay	23250757	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23250757	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

non-lysosomal glucosylceramidase

NLGase	beta-glucocerebrosidase 2
beta-glucosidase 2	bile acid beta-glucosidase GBA2
bile acid glucosyl transferase GBA2	cholesterol glucosyltransferase GBA2
cholesteryl-beta-glucosidase GBA2	glucosidase, beta (bile acid) 2
glucosylceramidase 2	no

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129411	Sinbaglustat		98.60%	Unkown
HY-RS05302	GBA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18361	Gba2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24840	Gba2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gba2	NCBI	NCBI:57704

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