2. Gene
  3. Large2 - LARGE xylosyl- and glucuronyltransferase 2 Gene

Large2 - LARGE xylosyl- and glucuronyltransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Largel; Gyltl1b; mKIAA4105; 5730485C17Rik

Gene ID: 228366 | Gene type: protein coding

About Large2

Summary

Enables dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Located in intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; lung; sensory organ; skin; and urinary system. Orthologous to human LARGE2 (LARGE xylosyl- and glucuronyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Large2 Products(5)

mRNA Protein Name
NM_001166633.2 NP_001160105.1 xylosyl- and glucuronyltransferase LARGE2 isoform 2 precursor
NM_001290773.1 NP_001277702.1 xylosyl- and glucuronyltransferase LARGE2 isoform 3 precursor
NM_001290774.1 NP_001277703.1 xylosyl- and glucuronyltransferase LARGE2 isoform 4
NM_001290775.1 NP_001277704.1 xylosyl- and glucuronyltransferase LARGE2 isoform 5
NM_172670.3 NP_766258.2 xylosyl- and glucuronyltransferase LARGE2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables dystroglycan binding IDA
IDA: Inferred from direct assay
25138275 MGI
enables glucuronosyltransferase activity IDA
IDA: Inferred from direct assay
23125099 MGI
enables glycosyltransferase activity IMP
IMP: Inferred from mutant phenotype
25138275 MGI
enables xylosyltransferase activity IDA
IDA: Inferred from direct assay
23125099 MGI
Biological Process GO Annotation Evidence Reference Source
involved in protein O-linked mannosylation IDA
IDA: Inferred from direct assay
23125099 MGI
Cellular Component GO Annotation Evidence Reference Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
25138275 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

xylosyl- and glucuronyltransferase LARGE2

LARGE xylosyl- and glucuronyltransferase 2

glycoslytransferase-like 1B

glycosyltransferase-like 1B

glycosyltransferase-like protein LARGE2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07525 LARGE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21879 Large2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28396 Large2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Large2 NCBI NCBI:120071