Zp3 - zona pellucida glycoprotein 3 Gene

Mus musculus

Also known as Zp-3

Gene ID: 22788 | Gene type: protein coding

About Zp3

Summary

Enables receptor ligand activity. A structural constituent of egg coat. Involved in several processes, including oogenesis; positive regulation of acrosome reaction; and regulation of gene expression. Acts upstream of or within binding activity of sperm to zona pellucida. Located in collagen-containing extracellular matrix and plasma membrane. Is expressed in ovary and testis. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]

Zp3 Products(1)

mRNA	Protein	Name
NM_011776.1	NP_035906.1	zona pellucida sperm-binding protein 3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7604284	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	10793136	MGI
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	17258189	MGI
enables structural constituent of egg coat	IMP IMP: Inferred from mutant phenotype	14645511	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within binding of sperm to zona pellucida	IDA IDA: Inferred from direct assay	11739644	MGI
involved in binding of sperm to zona pellucida	IGI IGI: Inferred from genetic interaction	9609824	MGI
involved in binding of sperm to zona pellucida	IMP IMP: Inferred from mutant phenotype	11417900	MGI
acts upstream of or within binding of sperm to zona pellucida	IPI IPI: Inferred from physical interaction	9374408	MGI
involved in blastocyst formation	IMP IMP: Inferred from mutant phenotype	20382503	MGI
involved in egg coat formation	IMP IMP: Inferred from mutant phenotype	14645511	MGI
involved in humoral immune response mediated by circulating immunoglobulin	IDA IDA: Inferred from direct assay	20382503	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18667753	MGI
involved in oocyte development	IMP IMP: Inferred from mutant phenotype	18420282	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18667753	MGI
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	15579591	MGI
involved in positive regulation of acrosome reaction	IDA IDA: Inferred from direct assay	10793136	MGI
involved in positive regulation of antral ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	18420282	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	18667753	MGI
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	15579591	MGI
involved in positive regulation of leukocyte migration	IDA IDA: Inferred from direct assay	18667753	MGI
involved in positive regulation of ovarian follicle development	IDA IDA: Inferred from direct assay	18667753	MGI
involved in positive regulation of ovarian follicle development	IMP IMP: Inferred from mutant phenotype	15579591	MGI
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	15579591	MGI
involved in positive regulation of type IV hypersensitivity	IDA IDA: Inferred from direct assay	15579591	MGI
involved in regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	10793136	MGI
involved in regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	17258189	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	11906903	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11417900	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zona pellucida sperm-binding protein 3

sperm receptor	zona pellucida glycoprotein ZP3
zona pellucida protein C

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16188	ZP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17941	Zp3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24412	Zp3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zp3	NCBI	NCBI:7784

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