Ikzf3 - IKAROS family zinc finger 3 Gene

Mus musculus

Also known as Aiolos; Zfpn1a3; Znfn1a3; 5830411O07Rik

Gene ID: 22780 | Gene type: protein coding

About Ikzf3

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of B cell differentiation; and regulation of B cell proliferation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in Peyer's patch; genitourinary system; immune system; lung; and spinal cord. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Ikzf3 Products(1)

mRNA	Protein	Name
NM_011771.1	NP_035901.1	zinc finger protein Aiolos

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9155026	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	34155405	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9155026	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9155026	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9155026	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	34155405	MGI
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	34155405	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9155026	MGI
involved in regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	9806640	MGI
involved in regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	9806640	MGI
involved in regulation of lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	9155026	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9155026	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9155026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein Aiolos

ikaros family zinc finger protein 3

zinc finger protein, subfamily 1A, 3 (Aiolos)

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144841	Cemsidomide	Degrader	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161101	MG degrader 1		99.83%	Unkown
HY-168614	MGD-4	Degrader	/	Unkown
HY-168615	MGD-28	Degrader	99.73%	Unkown
HY-169077	IKZF3 degrader 1	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ikzf3	NCBI	NCBI:22806

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