Ikzf1 - IKAROS family zinc finger 1 Gene

Mus musculus

Also known as LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik

Gene ID: 22778 | Gene type: protein coding

About Ikzf1

Summary

The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Ikzf1 Products(77)

mRNA	Protein	Name
NM_001025597.3	NP_001020768.1	DNA-binding protein Ikaros isoform 1
NM_001301863.2	NP_001288792.1	DNA-binding protein Ikaros isoform 1
NM_001301865.2	NP_001288794.1	DNA-binding protein Ikaros isoform 2
NM_001301866.2	NP_001288795.1	DNA-binding protein Ikaros isoform 3
NM_001301868.2	NP_001288797.1	DNA-binding protein Ikaros isoform 4
NM_001404490.1	NP_001391419.1	DNA-binding protein Ikaros isoform 5
NM_001404491.1	NP_001391420.1	DNA-binding protein Ikaros isoform 6
NM_001404492.1	NP_001391421.1	DNA-binding protein Ikaros isoform 7
NM_001404493.1	NP_001391422.1	DNA-binding protein Ikaros isoform 7
NM_001404494.1	NP_001391423.1	DNA-binding protein Ikaros isoform 7
NM_001404495.1	NP_001391424.1	DNA-binding protein Ikaros isoform 8
NM_001404496.1	NP_001391425.1	DNA-binding protein Ikaros isoform 9
NM_001404497.1	NP_001391426.1	DNA-binding protein Ikaros isoform 9
NM_001404498.1	NP_001391427.1	DNA-binding protein Ikaros isoform 1
NM_001404499.1	NP_001391428.1	DNA-binding protein Ikaros isoform 1
NM_001404500.1	NP_001391429.1	DNA-binding protein Ikaros isoform 1
NM_001404501.1	NP_001391430.1	DNA-binding protein Ikaros isoform 1
NM_001404502.1	NP_001391431.1	DNA-binding protein Ikaros isoform 1
NM_001404503.1	NP_001391432.1	DNA-binding protein Ikaros isoform 1
NM_001404504.1	NP_001391433.1	DNA-binding protein Ikaros isoform 1
NM_001404505.1	NP_001391434.1	DNA-binding protein Ikaros isoform 1
NM_001404506.1	NP_001391435.1	DNA-binding protein Ikaros isoform 1
NM_001404507.1	NP_001391436.1	DNA-binding protein Ikaros isoform 4
NM_001404508.1	NP_001391437.1	DNA-binding protein Ikaros isoform 4
NM_001404509.1	NP_001391438.1	DNA-binding protein Ikaros isoform 4
NM_001404510.1	NP_001391439.1	DNA-binding protein Ikaros isoform 10
NM_001404511.1	NP_001391440.1	DNA-binding protein Ikaros isoform 11
NM_001404512.1	NP_001391441.1	DNA-binding protein Ikaros isoform 11
NM_001404513.1	NP_001391442.1	DNA-binding protein Ikaros isoform 12
NM_001404514.1	NP_001391443.1	DNA-binding protein Ikaros isoform 13
NM_001404515.1	NP_001391444.1	DNA-binding protein Ikaros isoform 14
NM_001404516.1	NP_001391445.1	DNA-binding protein Ikaros isoform 14
NM_001404517.1	NP_001391446.1	DNA-binding protein Ikaros isoform 14
NM_001404518.1	NP_001391447.1	DNA-binding protein Ikaros isoform 15
NM_001404519.1	NP_001391448.1	DNA-binding protein Ikaros isoform 15
NM_001404520.1	NP_001391449.1	DNA-binding protein Ikaros isoform 15
NM_001404521.1	NP_001391450.1	DNA-binding protein Ikaros isoform 15
NM_001404522.1	NP_001391451.1	DNA-binding protein Ikaros isoform 15
NM_001404523.1	NP_001391452.1	DNA-binding protein Ikaros isoform 16
NM_001404524.1	NP_001391453.1	DNA-binding protein Ikaros isoform 17
NM_001404525.1	NP_001391454.1	DNA-binding protein Ikaros isoform 18
NM_001404526.1	NP_001391455.1	DNA-binding protein Ikaros isoform 18
NM_001404527.1	NP_001391456.1	DNA-binding protein Ikaros isoform 19
NM_001404531.1	NP_001391460.1	DNA-binding protein Ikaros isoform 19
NM_001404532.1	NP_001391461.1	DNA-binding protein Ikaros isoform 19
NM_001404533.1	NP_001391462.1	DNA-binding protein Ikaros isoform 19
NM_001404534.1	NP_001391463.1	DNA-binding protein Ikaros isoform 20
NM_001404535.1	NP_001391464.1	DNA-binding protein Ikaros isoform 21
NM_001404537.1	NP_001391466.1	DNA-binding protein Ikaros isoform 22
NM_001404539.1	NP_001391468.1	DNA-binding protein Ikaros isoform 23
NM_001404540.1	NP_001391469.1	DNA-binding protein Ikaros isoform 23
NM_001404542.1	NP_001391471.1	DNA-binding protein Ikaros isoform 23
NM_001404543.1	NP_001391472.1	DNA-binding protein Ikaros isoform 2
NM_001404544.1	NP_001391473.1	DNA-binding protein Ikaros isoform 2
NM_001404545.1	NP_001391474.1	DNA-binding protein Ikaros isoform 2
NM_001404547.1	NP_001391476.1	DNA-binding protein Ikaros isoform 2
NM_001404549.1	NP_001391478.1	DNA-binding protein Ikaros isoform 2
NM_001404550.1	NP_001391479.1	DNA-binding protein Ikaros isoform 24
NM_001404551.1	NP_001391480.1	DNA-binding protein Ikaros isoform 24
NM_001404552.1	NP_001391481.1	DNA-binding protein Ikaros isoform 24
NM_001404553.1	NP_001391482.1	DNA-binding protein Ikaros isoform 25
NM_001404554.1	NP_001391483.1	DNA-binding protein Ikaros isoform 26
NM_001404555.1	NP_001391484.1	DNA-binding protein Ikaros isoform 3
NM_001404556.1	NP_001391485.1	DNA-binding protein Ikaros isoform 3
NM_001404557.1	NP_001391486.1	DNA-binding protein Ikaros isoform 3
NM_001404558.1	NP_001391487.1	DNA-binding protein Ikaros isoform 27
NM_001404559.1	NP_001391488.1	DNA-binding protein Ikaros isoform 27
NM_001404560.1	NP_001391489.1	DNA-binding protein Ikaros isoform 27
NM_001404561.1	NP_001391490.1	DNA-binding protein Ikaros isoform 27
NM_001404562.1	NP_001391491.1	DNA-binding protein Ikaros isoform 28
NM_001404563.1	NP_001391492.1	DNA-binding protein Ikaros isoform 28
NM_001404564.1	NP_001391493.1	DNA-binding protein Ikaros isoform 29
NM_001404565.1	NP_001391494.1	DNA-binding protein Ikaros isoform 30
NM_001404567.1	NP_001391496.1	DNA-binding protein Ikaros isoform 30
NM_001404568.1	NP_001391497.1	DNA-binding protein Ikaros isoform 30
NM_001404569.1	NP_001391498.1	DNA-binding protein Ikaros isoform 31
NM_009578.4	NP_033604.2	DNA-binding protein Ikaros isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11805317	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7969165	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23071339	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15841184	MGI
enables poly-pyrimidine tract binding	IDA IDA: Inferred from direct assay	21245044	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9155026	MGI
enables sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	7923373	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	7969165	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	7923373	MGI
acts upstream of or within Peyer's patch development	IMP IMP: Inferred from mutant phenotype	7923373	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	7923373	MGI
acts upstream of or within amacrine cell differentiation	IDA IDA: Inferred from direct assay	25654255	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	21245044	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15841184	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	16467156	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	11805317	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	7923373	MGI
acts upstream of or within natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	7923373	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15767674	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18804520	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12617992	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7969165	MGI
acts upstream of or within positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP IMP: Inferred from mutant phenotype	21245044	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21245044	MGI
acts upstream of or within positive regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	16467156	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16467156	MGI
acts upstream of or within positive regulation of neutrophil differentiation	IMP IMP: Inferred from mutant phenotype	12406904	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15841184	MGI
acts upstream of or within positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21245044	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11805317	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23071339	MGI
acts upstream of or within retinal bipolar neuron differentiation	IDA IDA: Inferred from direct assay	25654255	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	7923373	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	7969165	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	15767674	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	21245044	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA-binding protein Ikaros

ikaros family zinc finger protein 1	lymphoid transcription factor LyF-1
zinc finger protein, subfamily 1A, 1 (Ikaros)

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144841	Cemsidomide	Degrader	99.54%	Phase 2
HY-145776	ALV1	Inhibitor	98.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168614	MGD-4	Degrader	/	Unkown
HY-168615	MGD-28	Degrader	99.73%	Unkown
HY-160531	IKZF1-degrader-1	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ikzf1	NCBI	NCBI:10320

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