2. Gene
  3. Ndufs1 - NADH:ubiquinone oxidoreductase core subunit S1 Gene

Ndufs1 - NADH:ubiquinone oxidoreductase core subunit S1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 5830412M15Rik; 9930026A05Rik

Gene ID: 227197 | Gene type: protein coding

About Ndufs1

Summary

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]

Ndufs1 Products(4)

mRNA Protein Name
NM_001160038.1 NP_001153510.1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor
NM_001160039.1 NP_001153511.1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor
NM_001160040.1 NP_001153512.1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor
NM_145518.2 NP_663493.2 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NADH dehydrogenase (ubiquinone) activity IMP
IMP: Inferred from mutant phenotype
27799543 MGI
enables electron transfer activity IMP
IMP: Inferred from mutant phenotype
27799543 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
32072193 MGI
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27799543 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
32072193 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

CI-75kD

NADH dehydrogenase (ubiquinone) Fe-S protein 1

complex I-75kD

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09157 NDUFS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21162 Ndufs1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndufs1 NCBI NCBI:4719