Yy1 - YY1 transcription factor Gene

Mus musculus

Also known as YY-1; NF-E1

Gene ID: 22632 | Gene type: protein coding

About Yy1

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including immune system development; negative regulation of pri-miRNA transcription by RNA polymerase II; and response to UV-C. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including anterior/posterior pattern specification; camera-type eye morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Part of PcG protein complex; chromatin silencing complex; and transcription regulator complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; female reproductive system; and hemolymphoid system gland. Used to study pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Yy1 Products(1)

mRNA	Protein	Name
NM_009537.4	NP_033563.2	transcriptional repressor protein YY1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12527199	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11861914	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20843790	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17107999	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24137001	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17107999	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23942234	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	23531880	MGI
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	18026119	MGI
acts upstream of or within RNA localization	IMP IMP: Inferred from mutant phenotype	21729784	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16624538	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16624538	MGI
acts upstream of or within camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	16624538	MGI
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	18026119	MGI
acts upstream of or within positive effect gene expression	IDA IDA: Inferred from direct assay	23942234	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	23531880	MGI
involved in immunoglobulin heavy chain V-D-J recombination	IMP IMP: Inferred from mutant phenotype	23531880	MGI
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	24675724	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9857059	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20843790	MGI
involved in positive regulation of DNA repair	IDA IDA: Inferred from direct assay	23979016	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	24101522	MGI
involved in positive regulation of telomere maintenance in response to DNA damage	IMP IMP: Inferred from mutant phenotype	23979016	MGI
involved in regulation of DNA repair	IDA IDA: Inferred from direct assay	23979016	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11861914	MGI
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	23979016	MGI
involved in response to UV-C	IMP IMP: Inferred from mutant phenotype	18026119	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	19786570	MGI
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	23979016	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	16624538	MGI
located in chromatin	IDA IDA: Inferred from direct assay	24675724	MGI
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	26658965	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9857059	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	11861914	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcriptional repressor protein YY1

UCR-motif DNA-binding protein	UCRBP transcription factor
Yin Yang 1	delta transcription factor
yin and yang 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15946	YY1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16713	Yy1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15947	YY1AP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23148	Yy1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Yy1	NCBI	NCBI:7528

Name
Email *

	Sorry, but the email address you supplied was invalid.