2. Gene
  3. Twnk - twinkle mtDNA helicase Gene

Twnk - twinkle mtDNA helicase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PEO; Peo1; Twinl; D19Ertd626e

Gene ID: 226153 | Gene type: protein coding

About Twnk

Summary

Enables DNA helicase activity. Involved in mitochondrial DNA replication. Acts upstream of or within DNA unwinding involved in DNA replication. Located in mitochondrion. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase). [provided by Alliance of Genome Resources, Apr 2022]

Twnk Products(3)

mRNA Protein Name
NM_001348254.1 NP_001335183.1 twinkle mtDNA helicase isoform 3
NM_001348259.1 NP_001335188.1 twinkle mtDNA helicase isoform 2
NM_153796.4 NP_722491.2 twinkle mtDNA helicase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA helicase activity IDA
IDA: Inferred from direct assay
11431692 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
11431692 MGI
involved in mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
18971204 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
11431692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twinkle mtDNA helicase

T7 gp4-like protein with intramitochondrial nucleoid localization

progressive external ophthalmoplegia 1 protein homolog

putative T7-like mitochodrial DNA helicase twinky

twinkle protein, mitochondrial

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15283 TWNK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20832 Twnk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27346 Twnk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twnk NCBI NCBI:56652