2. Gene
  3. Nox3 - NADPH oxidase 3 Gene

Nox3 - NADPH oxidase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as het; GP91-3; nmf250

Gene ID: 224480 | Gene type: protein coding

About Nox3

Summary

This gene encodes a member of the NOX family of NADPH oxidases. These Enzymes catalyze the transfer of electrons from NADPH to molecular oxygen to produce superoxide and other Reactive Oxygen Species (ROS). The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia, which are crystalline structures of the inner ear involved in the perception of gravity and linear acceleration. In mouse mutations of this gene lead to the absence of otoconia and vestibular dysfunction. [provided by RefSeq, Jun 2013]

Nox3 Products(1)

mRNA Protein Name
NM_198958.2 NP_945196.2 NADPH oxidase 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables heme binding IDA
IDA: Inferred from direct assay
17140397 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17140397 MGI
enables superoxide-generating NAD(P)H oxidase activity IDA
IDA: Inferred from direct assay
17140397 MGI
enables superoxide-generating NAD(P)H oxidase activity IMP
IMP: Inferred from mutant phenotype
15326186 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within detection of gravity IMP
IMP: Inferred from mutant phenotype
10491954 MGI
acts upstream of or within otolith development IMP
IMP: Inferred from mutant phenotype
10491954 MGI
acts upstream of or within response to gravity IMP
IMP: Inferred from mutant phenotype
12434016 MGI
acts upstream of or within temperature homeostasis IMP
IMP: Inferred from mutant phenotype
12434016 MGI
Cellular Component GO Annotation Evidence Reference Source
part of NADPH oxidase complex IDA
IDA: Inferred from direct assay
17140397 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17140397 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17140397 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NADPH oxidase 3

head-tilt

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-120801 APX-115 Inhibitor 99.08% Phase 2
HY-120801A APX-115 free base Inhibitor 99.54% Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126195 Fluoflavine Inhibitor 99.41% Unkown
HY-RS09460 NOX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20784 Nox3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27298 Nox3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nox3 NCBI NCBI:50508