Wnt7b - wingless-type MMTV integration site family, member 7B Gene

Mus musculus

Also known as Wnt-7b

Gene ID: 22422 | Gene type: protein coding

About Wnt7b

Summary

Enables chemoattractant activity involved in axon guidance and Frizzled binding activity. Involved in nervous system development and stem cell development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and oxygen homeostasis. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and sensory organ. Orthologous to human WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Apr 2022]

Wnt7b Products(3)

mRNA	Protein	Name
NM_001163633.1	NP_001157105.1	protein Wnt-7b isoform 3
NM_001163634.1	NP_001157106.1	protein Wnt-7b isoform 2
NM_009528.3	NP_033554.3	protein Wnt-7b isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemoattractant activity involved in axon guidance	IDA IDA: Inferred from direct assay	21106844	MGI
enables frizzled binding	IPI IPI: Inferred from physical interaction	15923619	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10866835	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18367557	MGI
involved in Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	21106844	MGI
acts upstream of or within anatomical structure regression	IMP IMP: Inferred from mutant phenotype	16163358	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	19129494	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	19129494	MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	16163358	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17804636	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15923619	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19690384	MGI
involved in cell proliferation in forebrain	IDA IDA: Inferred from direct assay	12843296	MGI
acts upstream of or within cellular metabolic process	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within central nervous system vasculogenesis	IGI IGI: Inferred from genetic interaction	19023080	MGI
involved in chemoattraction of dopaminergic neuron axon	IDA IDA: Inferred from direct assay	21106844	MGI
acts upstream of or within chorio-allantoic fusion	IMP IMP: Inferred from mutant phenotype	11543617	MGI
acts upstream of or within developmental growth involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within embryonic placenta morphogenesis	IMP IMP: Inferred from mutant phenotype	11543617	MGI
acts upstream of or within establishment or maintenance of polarity of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	19060336	MGI
involved in forebrain regionalization	IEP IEP: Inferred from expression pattern	15164427	MGI
acts upstream of or within homeostatic process	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within inner medullary collecting duct development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within intracellular oxygen homeostasis	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within lobar bronchus development	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	18343501	MGI
acts upstream of or within lung epithelium development	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within lung-associated mesenchyme development	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within metanephric collecting duct development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within metanephric epithelium development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within metanephric loop of Henle development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within metanephros morphogenesis	IMP IMP: Inferred from mutant phenotype	19060336	MGI
involved in negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	12843296	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	10781055	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	10781055	MGI
acts upstream of osteoblast differentiation	IDA IDA: Inferred from direct assay	15576404	MGI
acts upstream of or within outer medullary collecting duct development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19690384	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19690384	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15576404	MGI
acts upstream of or within renal inner medulla development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within renal outer medulla development	IMP IMP: Inferred from mutant phenotype	19060336	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	19690384	MGI
involved in stem cell development	IDA IDA: Inferred from direct assay	12843296	MGI
acts upstream of or within synapse organization	IGI IGI: Inferred from genetic interaction	16818724	MGI
acts upstream of or within trachea cartilage morphogenesis	IMP IMP: Inferred from mutant phenotype	18367557	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	16163358	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8167409	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-7b

wingless-related MMTV integration site 7B

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15841	WNT7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21808	Wnt7b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt7b	NCBI	NCBI:7477

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