2. Gene
  3. Nrros - negative regulator of reactive oxygen species Gene

Nrros - negative regulator of reactive oxygen species Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lrcc33; Lrrc33; E430025L02Rik

Gene ID: 224109 | Gene type: protein coding

About Nrros

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface and endoplasmic reticulum. Is expressed in embryo and thymus primordium. Orthologous to human NRROS (negative regulator of Reactive Oxygen Species). [provided by Alliance of Genome Resources, Apr 2022]

Nrros Products(3)

mRNA Protein Name
NM_001347181.1 NP_001334110.1 transforming growth factor beta activator LRRC33 isoform 2 precursor
NM_001347182.1 NP_001334111.1 transforming growth factor beta activator LRRC33 isoform 3
NM_146069.5 NP_666181.3 transforming growth factor beta activator LRRC33 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24739962 MGI
enables receptor ligand inhibitor activity IDA
IDA: Inferred from direct assay
29909984 MGI
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
29909984 MGI
Biological Process GO Annotation Evidence Reference Source
involved in immune response IMP
IMP: Inferred from mutant phenotype
24739962 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24739962 MGI
NOT involved in innate immune response IDA
IDA: Inferred from direct assay
29909984 MGI
involved in microglia development IMP
IMP: Inferred from mutant phenotype
28459434 MGI
involved in sequestering of TGFbeta in extracellular matrix IDA
IDA: Inferred from direct assay
29909984 MGI
NOT involved in superoxide metabolic process IDA
IDA: Inferred from direct assay
29909984 MGI
involved in superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
24739962 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
29909984 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
29909984 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24739962 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transforming growth factor beta activator LRRC33

leucine rich repeat containing 33

leucine-rich repeat-containing protein 33

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09581 NRROS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19727 Nrros Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26223 Nrros Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrros NCBI NCBI:375387