Wnt1 - wingless-type MMTV integration site family, member 1 Gene

Mus musculus

Also known as sw; Int-1; Wnt-1; swaying

Gene ID: 22408 | Gene type: protein coding

About Wnt1

Summary

Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; regulation of cellular protein metabolic process; and ubiquitin-dependent SMAD protein catabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast Cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human Wnt1 (Wnt family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Wnt1 Products(1)

mRNA	Protein	Name
NM_021279.4	NP_067254.1	proto-oncogene Wnt-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	10557084	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10866835	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15454084	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	10557084	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11029007	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Spemann organizer formation	IMP IMP: Inferred from mutant phenotype	9192640	MGI
acts upstream of or within T cell differentiation in thymus	IDA IDA: Inferred from direct assay	11265645	MGI
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	9192640	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	16054034	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	9652750	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	12121999	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15143170	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
involved in cell proliferation in midbrain	IDA IDA: Inferred from direct assay	14557550	MGI
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	10557084	MGI
involved in central nervous system morphogenesis	IMP IMP: Inferred from mutant phenotype	2202907	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	8848044	MGI
involved in cerebellum formation	IMP IMP: Inferred from mutant phenotype	2202907	MGI
acts upstream of or within diencephalon development	IGI IGI: Inferred from genetic interaction	18094027	MGI
involved in dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	23324743	MGI
involved in embryonic axis specification	IMP IMP: Inferred from mutant phenotype	2534596	MGI
involved in embryonic brain development	IDA IDA: Inferred from direct assay	15121182	MGI
acts upstream of fat cell differentiation	IDA IDA: Inferred from direct assay	15728361	MGI
acts upstream of or within forebrain anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	18094027	MGI
acts upstream of hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	15961523	MGI
acts upstream of or within metencephalon development	IMP IMP: Inferred from mutant phenotype	2205396	MGI
involved in midbrain development	IDA IDA: Inferred from direct assay	14557550	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	2205396	MGI
involved in midbrain development	IMP IMP: Inferred from mutant phenotype	2202907	MGI
involved in midbrain dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	19951692	MGI
involved in midbrain dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	23324743	MGI
acts upstream of or within midbrain-hindbrain boundary development	IMP IMP: Inferred from mutant phenotype	2205396	MGI
acts upstream of or within midbrain-hindbrain boundary maturation during brain development	IMP IMP: Inferred from mutant phenotype	8555108	MGI
acts upstream of or within myoblast fusion	IDA IDA: Inferred from direct assay	15282335	MGI
acts upstream of or within myoblast fusion	IGI IGI: Inferred from genetic interaction	15282335	MGI
acts upstream of or within myotube differentiation	IGI IGI: Inferred from genetic interaction	15282335	MGI
involved in negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	9473323	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	10937998	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	10937998	MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21752258	MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16601693	MGI
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16601693	MGI
involved in neurogenesis	IDA IDA: Inferred from direct assay	14557550	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	16339193	MGI
acts upstream of or within neuron fate determination	IMP IMP: Inferred from mutant phenotype	16339193	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9356179	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12937339	MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9160667	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15143170	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9769173	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19951692	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15574752	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	11877374	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8710372	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	11336703	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proto-oncogene Wnt-1

proto-oncogene Int-1	proto-oncogene protein Wnt-1
wingless-related MMTV integration site 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164528	SJ26	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt1	NCBI	NCBI:7471

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