2. Gene
  3. Adamts20 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 Gene

Adamts20 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as bt; Adamst20

Gene ID: 223838 | Gene type: protein coding

About Adamts20

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Certain mutations in this gene cause defective development of neural crest-derived melanoblasts resulting in a "belted" phenotype that is characterized by white spots in the lumbar region. [provided by RefSeq, Jul 2016]

Adamts20 Products(3)

mRNA Protein Name
NM_001164785.1 NP_001158257.1 A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 2 precursor
NM_001164786.1 NP_001158258.1 A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 3 precursor
NM_177431.5 NP_803180.3 A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
18454205 MGI
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
12562771 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
18454205 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18454205 MGI
acts upstream of melanocyte differentiation IGI
IGI: Inferred from genetic interaction
18454205 MGI
acts upstream of melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
18454205 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18454205 MGI
acts upstream of or within positive regulation of melanocyte differentiation IGI
IGI: Inferred from genetic interaction
18454205 MGI
acts upstream of or within positive regulation of melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
18454205 MGI
acts upstream of or within positive regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
18454205 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
12562771 MGI
acts upstream of or within regulation of developmental pigmentation IGI
IGI: Inferred from genetic interaction
18454205 MGI
acts upstream of or within regulation of developmental pigmentation IMP
IMP: Inferred from mutant phenotype
14138974 MGI
acts upstream of signal transduction IMP
IMP: Inferred from mutant phenotype
18454205 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
18454205 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 20

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00302 ADAMTS20 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19289 Adamts20 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25779 Adamts20 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts20 NCBI NCBI:80070