Ezr - ezrin Gene

Mus musculus

Also known as p81; Vil2

Gene ID: 22350 | Gene type: protein coding

About Ezr

Summary

Enables disordered domain specific binding activity and protein C-terminus binding activity. Involved in several processes, including intestinal D-glucose absorption; positive regulation of protein localization to plasma membrane; and terminal web assembly. Acts upstream of or within establishment or maintenance of apical/basal cell polarity and receptor internalization. Located in several cellular components, including brush border; microvillus; and uropod. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human EZR (ezrin). [provided by Alliance of Genome Resources, Apr 2022]

Ezr Products(1)

mRNA	Protein	Name
NM_009510.2	NP_033536.2	ezrin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables disordered domain specific binding	IDA IDA: Inferred from direct assay	18321067	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9472040	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within establishment or maintenance of apical/basal cell polarity	IMP IMP: Inferred from mutant phenotype	15177033	MGI
involved in intestinal D-glucose absorption	IGI IGI: Inferred from genetic interaction	22114352	MGI
NOT involved in microvillus assembly	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in positive regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in positive regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	29720403	MGI
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	29720403	MGI
acts upstream of or within receptor internalization	IMP IMP: Inferred from mutant phenotype	16365167	MGI
involved in regulation of microvillus length	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in terminal web assembly	IGI IGI: Inferred from genetic interaction	22114352	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	9890997	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	14625387	MGI
located in brush border	IDA IDA: Inferred from direct assay	22114352	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	14996907	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	17122142	MGI
located in microvillus	IDA IDA: Inferred from direct assay	9472040	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21377456	MGI
located in uropod	IDA IDA: Inferred from direct assay	11728336	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ezrin

cytovillin

villin-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04623	EZR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19860	Ezr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26360	Ezr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ezr	NCBI	NCBI:7430

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