Usf2 - upstream transcription factor 2 Gene

Mus musculus

Also known as Usf-2; bHLHb12

Gene ID: 22282 | Gene type: protein coding

About Usf2

Summary

Enables DNA binding activity. Involved in lipid homeostasis and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within lactation; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human USF2 (upstream transcription factor 2, c-Fos interacting). [provided by Alliance of Genome Resources, Apr 2022]

Usf2 Products(1)

mRNA	Protein	Name
NM_011680.2	NP_035810.1	upstream stimulatory factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7523363	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9890958	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23749757	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	9890958	MGI
involved in glucose mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	9890958	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	12907752	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	9890958	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15466854	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9890958	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IMP IMP: Inferred from mutant phenotype	9890958	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7523363	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12907752	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

upstream stimulatory factor 2

major late transcription factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15514	USF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21454	Usf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27972	Usf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Usf2	NCBI	NCBI:7392

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