1. Gene
  2. Unc119 - unc-119 lipid binding chaperone Gene

Unc119 - unc-119 lipid binding chaperone Gene

Mus musculus

Also known as Rg4; HRG4; MRG4; Rtg4; Unc119h; D11Bhm52

Gene ID: 22248 | Gene type: protein coding

About Unc119

Summary

The protein encoded by this gene is multifunctional, affecting trafficking of transducin in rod photoreceptors, interacting with src-type tyrosine kinases through SH2 and SH3 interacting domains, and aiding the uptake of bacteria through endocytosis. In addition, the encoded protein acts as a lipid-binding chaperone to help localize some myristoylated proteins correctly. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Unc119 Products(10)

mRNA Protein Name
NM_001313985.1 NP_001300914.1 protein unc-119 homolog A isoform 1
NM_001313986.1 NP_001300915.1 protein unc-119 homolog A isoform 3
NM_001313987.1 NP_001300916.1 protein unc-119 homolog A isoform 4
NM_001313988.1 NP_001300917.1 protein unc-119 homolog A isoform 5
NM_011676.3 NP_035806.1 protein unc-119 homolog A isoform 2
NM_001313985.1 NP_001300914.1 protein unc-119 homolog A isoform 1
NM_001313986.1 NP_001300915.1 protein unc-119 homolog A isoform 3
NM_001313987.1 NP_001300916.1 protein unc-119 homolog A isoform 4
NM_001313988.1 NP_001300917.1 protein unc-119 homolog A isoform 5
NM_011676.3 NP_035806.1 protein unc-119 homolog A isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19781630 MGI
Biological Process GO Annotation Evidence Reference Source
involved in lipoprotein transport IMP
IMP: Inferred from mutant phenotype
21642972 MGI
involved in negative regulation of caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
19781630 MGI
involved in negative regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
19781630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein unc-119 homolog A

retinal gene 4

retinal protein 4

Orthologs Information

Species Symbol Source ID
Homo sapiens Unc119 NCBI NCBI:9094