Ucp1 - uncoupling protein 1 (mitochondrial, proton carrier) Gene

Mus musculus

Also known as Ucp; Slc25a7

Gene ID: 22227 | Gene type: protein coding

About Ucp1

Summary

Enables long-chain fatty acid binding activity; Oxidative Phosphorylation uncoupler activity; and purine ribonucleotide binding activity. Involved in several processes, including cellular response to cold; diet induced thermogenesis; and positive regulation of cold-induced thermogenesis. Acts upstream of or within brown fat cell differentiation and regulation of transcription by RNA polymerase II. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; adrenal gland; submandibular gland; testis; and thymus. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ucp1 Products(1)

mRNA	Protein	Name
NM_009463.3	NP_033489.1	mitochondrial brown fat uncoupling protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables long-chain fatty acid binding	IDA IDA: Inferred from direct assay	23063128	MGI
enables oxidative phosphorylation uncoupler activity	IDA IDA: Inferred from direct assay	12910269	MGI
enables oxidative phosphorylation uncoupler activity	IMP IMP: Inferred from mutant phenotype	20416274	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12910269	MGI
enables purine ribonucleotide binding	IDA IDA: Inferred from direct assay	23063128	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	9139827	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	28763438	MGI
involved in brown fat cell differentiation	IEP IEP: Inferred from expression pattern	15567149	MGI
involved in cellular response to cold	IDA IDA: Inferred from direct assay	28763438	MGI
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	23063128	MGI
involved in cellular response to hormone stimulus	IMP IMP: Inferred from mutant phenotype	27027295	MGI
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	27027295	MGI
involved in diet induced thermogenesis	IMP IMP: Inferred from mutant phenotype	19187776	MGI
involved in mitochondrial transmembrane transport	IDA IDA: Inferred from direct assay	23063128	MGI
involved in mitochondrial transmembrane transport	IMP IMP: Inferred from mutant phenotype	20416274	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28630339	MGI
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	23063128	MGI
involved in regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	20416274	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17670746	MGI
involved in response to nutrient levels	IMP IMP: Inferred from mutant phenotype	19187776	MGI
involved in response to temperature stimulus	IMP IMP: Inferred from mutant phenotype	19187776	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial envelope	IDA IDA: Inferred from direct assay	12910269	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	23063128	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11940593	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial brown fat uncoupling protein 1

UCP 1	solute carrier family 25 member 7
thermogenin	uncoupling protein 1, mitochondrial
uncoupling protein, mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107574	TC-E 5003		98.03%	Unkown
HY-N0704	Agrimol B		99.75%	Unkown
HY-110148	WWL113	Inhibitor	99.72%	Unkown
HY-153813	Z16078526	Modulator	98.13%	Unkown
HY-135115	Oleuropein Aglycone	Inhibitor	98.46%	Unkown
HY-133095	BML-260	Activator	99.65%	Unkown
HY-129692	Withanone	Inhibitor	93.28%	Unkown
HY-148973	ZW290	Inhibitor	99.60%	Unkown
HY-RS16955	Ucp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176148	ZGL-18		/	Unkown
HY-RS15410	UCP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153812	AST 7062601		/	Unkown
HY-RS23398	Ucp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ucp1	NCBI	NCBI:7350

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