2. Gene
  3. Ube3a - ubiquitin protein ligase E3A Gene

Ube3a - ubiquitin protein ligase E3A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hpve6a; 4732496B02; 5830462N02Rik; A130086L21Rik

Gene ID: 22215 | Gene type: protein coding

About Ube3a

Summary

Enables transcription coactivator activity and ubiquitin protein Ligase activity. Involved in positive regulation of Golgi lumen acidification and regulation of circadian rhythm. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of phosphatidylinositol 3-kinase signaling; and reproductive structure development. Located in cytosol and nucleus. Is expressed in central nervous system and retina. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein Ligase E3A). [provided by Alliance of Genome Resources, Apr 2022]

Ube3a Products(10)

mRNA Protein Name
NM_001033962.2 NP_001029134.1 ubiquitin-protein ligase E3A isoform 3
NM_001393666.1 NP_001380595.1 ubiquitin-protein ligase E3A isoform 2
NM_001393668.1 NP_001380597.1 ubiquitin-protein ligase E3A isoform 3
NM_001393669.1 NP_001380598.1 ubiquitin-protein ligase E3A isoform 4
NM_001393670.1 NP_001380599.1 ubiquitin-protein ligase E3A isoform 4
NM_001393671.1 NP_001380600.1 ubiquitin-protein ligase E3A isoform 4
NM_001393672.1 NP_001380601.1 ubiquitin-protein ligase E3A isoform 4
NM_001393973.1 NP_001380902.1 ubiquitin-protein ligase E3A isoform 2
NM_011668.3 NP_035798.2 ubiquitin-protein ligase E3A isoform 2
NM_173010.4 NP_766598.1 ubiquitin-protein ligase E3A isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9182527 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16254014 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
9182527 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within androgen receptor signaling pathway IPI
IPI: Inferred from physical interaction
16254014 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26166566 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26166566 MGI
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
30020076 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
11756548 MGI
involved in positive regulation of Golgi lumen acidification IMP
IMP: Inferred from mutant phenotype
23447592 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16254014 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16254014 MGI
acts upstream of or within prostate gland growth IMP
IMP: Inferred from mutant phenotype
11756548 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
30020076 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
9182527 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
24728990 MGI
involved in regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
30020076 MGI
acts upstream of or within sperm entry IMP
IMP: Inferred from mutant phenotype
11756548 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16254014 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
9182527 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26166566 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26166566 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9182527 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
27339004 MGI
is active in synaptic vesicle IDA
IDA: Inferred from direct assay
27339004 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-protein ligase E3A

E6-AP ubiquitin protein ligase

HECT-type ubiquitin transferase E3A

oncogenic protein-associated protein E6-AP

ubiquitin conjugating enzyme E3A

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148130 Rugonersen Activator 91.12% Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148130A Rugonersen sodium 91.12% Unkown
HY-162683 (S)-PHA533533 Inhibitor 98.27% Unkown
HY-RS15368 UBE3A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20508 Ube3a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27016 Ube3a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ube3a NCBI NCBI:7337