Ube2b - ubiquitin-conjugating enzyme E2B Gene

Mus musculus

Also known as HR6B; E214K; Rad6b; mHR6B; E2-14k

Gene ID: 22210 | Gene type: protein coding

About Ube2b

Summary

Enables ubiquitin conjugating enzyme activity and ubiquitin protein Ligase binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including chromosome organization; positive regulation of reciprocal meiotic recombination; and sperm axoneme assembly. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human UBE2B (Ubiquitin Conjugating Enzyme E2 B). [provided by Alliance of Genome Resources, Apr 2022]

Ube2b Products(3)

mRNA	Protein	Name
NM_001362685.1	NP_001349614.1	ubiquitin-conjugating enzyme E2 B isoform 1
NM_001362686.1	NP_001349615.1	ubiquitin-conjugating enzyme E2 B isoform 2
NM_009458.5	NP_033484.3	ubiquitin-conjugating enzyme E2 B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12509447	MGI
enables ubiquitin conjugating enzyme activity	IGI IGI: Inferred from genetic interaction	14585983	MGI
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	14585983	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	12556476	MGI
acts upstream of or within chiasma assembly	IMP IMP: Inferred from mutant phenotype	12556476	MGI
acts upstream of or within chromatin organization	IMP IMP: Inferred from mutant phenotype	17488778	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	12556476	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	15169909	MGI
acts upstream of or within leptotene	IMP IMP: Inferred from mutant phenotype	17010969	MGI
acts upstream of or within meiotic telomere clustering	IMP IMP: Inferred from mutant phenotype	17010969	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12556476	MGI
acts upstream of or within negative regulation of developmental process	IMP IMP: Inferred from mutant phenotype	12556476	MGI
acts upstream of or within negative regulation of post-translational protein modification	IMP IMP: Inferred from mutant phenotype	17488778	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	12556476	MGI
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18339854	MGI
acts upstream of or within positive regulation of reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	12556476	MGI
acts upstream of or within sperm axoneme assembly	IMP IMP: Inferred from mutant phenotype	12672659	MGI
acts upstream of or within synaptonemal complex organization	IMP IMP: Inferred from mutant phenotype	12556476	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in XY body	IDA IDA: Inferred from direct assay	15383616	MGI
located in chromatin	IDA IDA: Inferred from direct assay	15383616	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 B

E2 ubiquitin-conjugating enzyme B	RAD6 homolog B
ubiquitin carrier protein B	ubiquitin-conjugating enzyme E2B, RAD6 homology
ubiquitin-protein ligase B

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15337	UBE2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20506	Ube2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27014	Ube2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ube2b	NCBI	NCBI:7320

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