2. Gene
  3. Txk - TXK tyrosine kinase Gene

Txk - TXK tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rlk; Btkl; PTK4; PTK-RL-18; A130089B16Rik

Gene ID: 22165 | Gene type: protein coding

About Txk

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; activation of Phospholipase C activity; and positive regulation of cytokine production. Acts upstream of or within NK T cell differentiation. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including hemolymphoid system; lung; male reproductive gland or organ; stomach mesentery; and vertebral axis musculature. Orthologous to human TXK (TXK tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Txk Products(4)

mRNA Protein Name
NM_001122754.2 NP_001116226.1 tyrosine-protein kinase TXK isoform 1
NM_001289494.1 NP_001276423.1 tyrosine-protein kinase TXK isoform 3
NM_001289495.1 NP_001276424.1 tyrosine-protein kinase TXK isoform 4
NM_013698.3 NP_038726.2 tyrosine-protein kinase TXK isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within NK T cell differentiation IGI
IGI: Inferred from genetic interaction
18292523 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10213685 MGI
involved in adaptive immune response IMP
IMP: Inferred from mutant phenotype
10213685 MGI
acts upstream of or within interleukin-4 production IGI
IGI: Inferred from genetic interaction
18292523 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
10213685 MGI
acts upstream of or within type II interferon production IGI
IGI: Inferred from genetic interaction
18292523 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase TXK

resting lymphocyte kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10644 Lck inhibitor 2 Inhibitor 99.73% Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-RS15285 TXK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-D2415 BODIPY-FL staurosporine / Unkown
HY-RS22085 Txk Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txk NCBI NCBI:7294