Ttk - Ttk protein kinase Gene

Mus musculus

Also known as PYT; esk; Esk1; Mps1

Gene ID: 22137 | Gene type: protein coding

About Ttk

Summary

Enables identical protein binding activity; kinetochore binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in mitotic spindle assembly checkpoint signaling. Acts upstream of or within several processes, including meiotic spindle assembly checkpoint signaling; protein localization to organelle; and protein phosphorylation. Located in kinetochore. Is expressed in brain; lung; metanephros; and ureteric tip. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ttk Products(3)

mRNA	Protein	Name
NM_001110265.2	NP_001103735.1	dual specificity protein kinase TTK isoform 2
NM_001284272.2	NP_001271201.1	dual specificity protein kinase TTK isoform 3
NM_009445.3	NP_033471.2	dual specificity protein kinase TTK isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21558374	MGI
enables kinetochore binding	IMP IMP: Inferred from mutant phenotype	25197064	MGI
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: Inferred from direct assay	1375325	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within female meiosis chromosome segregation	IMP IMP: Inferred from mutant phenotype	21558374	MGI
acts upstream of or within meiotic prometaphase I	IMP IMP: Inferred from mutant phenotype	21558374	MGI
acts upstream of or within meiotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21558374	MGI
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	25197064	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	1375325	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	1375325	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	1375325	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	1375325	MGI
acts upstream of or within protein localization to chromosome	IMP IMP: Inferred from mutant phenotype	21558374	MGI
acts upstream of or within protein localization to kinetochore	IMP IMP: Inferred from mutant phenotype	21558374	MGI
acts upstream of or within protein localization to meiotic spindle midzone	IMP IMP: Inferred from mutant phenotype	21558374	MGI
acts upstream of or within spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	32284991	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in kinetochore	IDA IDA: Inferred from direct assay	21558374	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity protein kinase TTK

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101340A	Luvixasertib hydrochloride	Inhibitor	99.63%	Phase 2
HY-143904	PROTAC TTK degrader-1	Antagonist	98.01%	Phase 2
HY-101340	Luvixasertib	Inhibitor	99.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14710	AZ3146	Inhibitor	99.42%	Unkown
HY-116673	TTK21	Activator	99.39%	Unkown
HY-108709	CC-671	Inhibitor	99.06%	Unkown
HY-100024	NTRC 0066-0	Inhibitor	99.01%	Unkown
HY-19544	JAK3-IN-1	Inhibitor	99.31%	Unkown
HY-168543	PROTAC MPS1 degrader 2	Degrader	/	Unkown
HY-144308	RMS-07	Inhibitor	/	Unkown
HY-132884	TTK inhibitor 3	Inhibitor	/	Unkown
HY-110347	Mps1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-123675	CFI-400936	Inhibitor	/	Unkown
HY-143905	PROTAC TTK degrader-2	Antagonist	/	Unkown
HY-160419	Mps1-IN-8	Inhibitor	/	Unkown
HY-162156	TTK inhibitor 4	Inhibitor	/	Unkown
HY-164955	TTK/PLK1-IN-1	Inhibitor	/	Unkown
HY-168540	PROTAC MPS1 degrader 1	Degrader	/	Unkown
HY-168542	TTK ligand 2		/	Unkown
HY-168545	TTK ligand 3		/	Unkown
HY-RS15226	TTK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16792	Ttk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21071	Ttbk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23232	Ttk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttk	NCBI	NCBI:7272

Name
Email *

	Sorry, but the email address you supplied was invalid.