Trex1 - three prime repair exonuclease 1 Gene

Mus musculus

Gene ID: 22040 | Gene type: protein coding

About Trex1

Summary

Enables several functions, including DNA binding activity; WW domain binding activity; and magnesium ion binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; cellular response to cytokine stimulus; and regulation of generation of precursor metabolites and energy. Located in cytosol; endoplasmic reticulum; and nuclear replication fork. Part of oligosaccharyltransferase complex and protein-DNA complex. Used to study Aicardi-Goutieres syndrome and cutaneous lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to human TREX1 (three prime repair exonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Trex1 Products(2)

mRNA	Protein	Name
NM_001012236.1	NP_001012236.1	three-prime repair exonuclease 1
NM_011637.6	NP_035767.4	three-prime repair exonuclease 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' exonuclease activity	IMP IMP: Inferred from mutant phenotype	15254239	MGI
enables 3'-5'-DNA exonuclease activity	IDA IDA: Inferred from direct assay	11279105	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	20871604	MGI
enables DNA binding, bending	IDA IDA: Inferred from direct assay	25848017	MGI
enables WW domain binding	IDA IDA: Inferred from direct assay	17355961	MGI
enables adenyl deoxyribonucleotide binding	IDA IDA: Inferred from direct assay	17293595	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	19158679	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	17293595	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	25848017	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11279105	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11279105	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	17293595	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CD86 biosynthetic process	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within DNA catabolic process	IDA IDA: Inferred from direct assay	20871604	MGI
acts upstream of or within DNA catabolic process	IMP IMP: Inferred from mutant phenotype	18724932	MGI
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	18045533	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	20511593	MGI
acts upstream of or within DNA duplex unwinding	IDA IDA: Inferred from direct assay	25848017	MGI
involved in DNA metabolic process	IDA IDA: Inferred from direct assay	11279105	MGI
acts upstream of or within DNA modification	IMP IMP: Inferred from mutant phenotype	24205360	MGI
acts upstream of or within DNA replication	IMP IMP: Inferred from mutant phenotype	20511593	MGI
acts upstream of or within DNA synthesis involved in UV-damage excision repair	IMP IMP: Inferred from mutant phenotype	23993650	MGI
acts upstream of or within G2 phase	IMP IMP: Inferred from mutant phenotype	18045533	MGI
acts upstream of or within T cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within activation of immune response	IMP IMP: Inferred from mutant phenotype	18045533	MGI
acts upstream of or within adaptive immune response	IMP IMP: Inferred from mutant phenotype	25848017	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within atrial cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	15254239	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	25848017	MGI
acts upstream of or within cellular response to UV	IDA IDA: Inferred from direct assay	20511593	MGI
acts upstream of or within cellular response to gamma radiation	IMP IMP: Inferred from mutant phenotype	18045533	MGI
acts upstream of or within cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	18045533	MGI
acts upstream of or within cellular response to interferon-beta	IDA IDA: Inferred from direct assay	19158679	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	23993650	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	23993650	MGI
acts upstream of or within cellular response to type I interferon	IMP IMP: Inferred from mutant phenotype	28835460	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	20871604	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	15254239	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23160154	MGI
acts upstream of or within generation of precursor metabolites and energy	IMP IMP: Inferred from mutant phenotype	28069950	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	15254239	MGI
acts upstream of or within heart process	IMP IMP: Inferred from mutant phenotype	15254239	MGI
acts upstream of or within immune complex formation	IMP IMP: Inferred from mutant phenotype	25848017	MGI
acts upstream of or within immune response	IMP IMP: Inferred from mutant phenotype	28835460	MGI
acts upstream of or within immune response in brain or nervous system	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response	IMP IMP: Inferred from mutant phenotype	25848017	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	15254239	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	23160154	MGI
acts upstream of or within interferon-alpha production	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	25848017	MGI
acts upstream of or within lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	25848017	MGI
acts upstream of or within macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within mitotic G1 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	18045533	MGI
acts upstream of or within negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18724932	MGI
acts upstream of or within organ or tissue specific immune response	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	26320659	MGI
acts upstream of or within regulation of T cell activation	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	23160154	MGI
acts upstream of or within regulation of cellular metabolic process	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within regulation of cellular metabolic process	IMP IMP: Inferred from mutant phenotype	28069950	MGI
acts upstream of or within regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	28069950	MGI
acts upstream of or within regulation of fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	28069950	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	23160154	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23160154	MGI
acts upstream of or within regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	28069950	MGI
acts upstream of or within regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	26320659	MGI
acts upstream of or within regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	20871604	MGI
acts upstream of or within regulation of lipid biosynthetic process	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within regulation of lysosome organization	IMP IMP: Inferred from mutant phenotype	23160154	MGI
acts upstream of or within regulation of protein complex stability	IMP IMP: Inferred from mutant phenotype	26320659	MGI
acts upstream of or within regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24218451	MGI
acts upstream of or within regulation of type I interferon production	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	20871604	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	28351661	MGI
acts upstream of or within retrotransposition	IMP IMP: Inferred from mutant phenotype	28835460	MGI
acts upstream of or within type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28351661	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17355961	MGI
located in cytosol	IDA IDA: Inferred from direct assay	28351661	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18724932	MGI
located in nuclear replication fork	IDA IDA: Inferred from direct assay	18045533	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18045533	MGI
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	26320659	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	25848017	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

three-prime repair exonuclease 1

3'-5' exonuclease TREX1	DNase III
three prime exonuclease 1	trophoblast expressed 1

Trex1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87119	TREX1 Antibody (YA6812)	WB, FC, IP	Mouse

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160785	TREX1-IN-1	Modulator	99.32%	Unkown
HY-173425	STING-IN-15	Inhibitor	99.04%	Unkown
HY-160786	TREX1-IN-3	Inhibitor	/	Unkown
HY-160786A	TREX1-IN-4	Inhibitor	/	Unkown
HY-RS15008	TREX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17776	Trex1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24243	Trex1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trex1	NCBI	NCBI:11277

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