Traf5 - TNF receptor-associated factor 5 Gene

Mus musculus

Gene ID: 22033 | Gene type: protein coding

About Traf5

Summary

Predicted to enable enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Involved in interleukin-17-mediated signaling pathway and regulation of gene expression. Acts upstream of or within positive regulation of cell population proliferation and signal transduction. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in genitourinary system and tongue muscle. Orthologous to human TRAF5 (TNF Receptor associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Traf5 Products(1)

mRNA	Protein	Name
NM_011633.2	NP_035763.2	TNF receptor-associated factor 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21822257	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	21822258	MGI
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15121867	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10449775	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	10449775	MGI
involved in signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	21822258	MGI
involved in signal transduction involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21822258	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD40 receptor complex	IDA IDA: Inferred from direct assay	20614026	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20614026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TNF receptor-associated factor 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14974	TRAF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22873	Traf5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf5	NCBI	NCBI:7188

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