Traf2 - TNF receptor-associated factor 2 Gene

Mus musculus

Gene ID: 22030 | Gene type: protein coding

About Traf2

Summary

Enables CD40 receptor binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to nitric oxide; programmed necrotic cell death; and regulation of JNK cascade. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF Receptor associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Traf2 Products(2)

mRNA	Protein	Name
NM_001290413.1	NP_001277342.1	TNF receptor-associated factor 2 isoform a
NM_009422.3	NP_033448.2	TNF receptor-associated factor 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CD40 receptor binding	IPI IPI: Inferred from physical interaction	20614026	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9418902	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18281285	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	8710854	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to nitric oxide	IMP IMP: Inferred from mutant phenotype	18007661	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	21822258	MGI
involved in interleukin-17-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in mRNA stabilization	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15121867	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	8710854	MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	11374864	MGI
acts upstream of or within programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	18007661	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	12958312	MGI
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	20614026	MGI
acts upstream of or within regulation of JNK cascade	IDA IDA: Inferred from direct assay	12958312	MGI
acts upstream of or within regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	12958312	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12958312	MGI
involved in signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	21822258	MGI
involved in signal transduction involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21822258	MGI
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	8710854	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD40 receptor complex	IDA IDA: Inferred from direct assay	20614026	MGI
part of IRE1-TRAF2-ASK1 complex	IDA IDA: Inferred from direct assay	12050113	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11821416	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20614026	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18007661	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	18007661	MGI
located in vesicle membrane	IDA IDA: Inferred from direct assay	18952128	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TNF receptor-associated factor 2

E3 ubiquitin-protein ligase TRAF2

RING-type E3 ubiquitin transferase TRAF2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16591	Birinapant		99.70%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100830	NCB-0846	Inhibitor	99.61%	Unkown
HY-138779	ICCB-19 hydrochloride		99.25%	Unkown
HY-134050	Apostatin-1		99.84%	Unkown
HY-124745	KY-05009		99.88%	Unkown
HY-145293	TNIK-IN-3	Inhibitor	99.88%	Unkown
HY-117469	Triptohypol C		95.44%	Unkown
HY-124762	TNIK-IN-1	Inhibitor	98.86%	Unkown
HY-156502	TINK-IN-1	Inhibitor	98.02%	Unkown
HY-156818	TNIK-IN-7	Inhibitor	99.90%	Unkown
HY-156817	TNIK-IN-6	Inhibitor	96.92%	Unkown
HY-122805	PF-794	Inhibitor	99.19%	Unkown
HY-100830A	NCB-0970	Control	/	Unkown
HY-145292	TNIK-IN-2	Inhibitor	99.68%	Unkown
HY-RS14968	TRAF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16859	Traf2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23300	Traf2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf2	NCBI	NCBI:7186

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