2. Gene
  3. Tpm2 - tropomyosin 2, beta Gene

Tpm2 - tropomyosin 2, beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tpm-2; Trop-2

Gene ID: 22004 | Gene type: protein coding

About Tpm2

Summary

This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]

Tpm2 Products(3)

mRNA Protein Name
NM_001277875.1 NP_001264804.1 tropomyosin beta chain isoform Tpm2.3
NM_001277876.1 NP_001264805.1 tropomyosin beta chain isoform Tpm2.1sm/cy
NM_009416.4 NP_033442.2 tropomyosin beta chain isoform Tpm2.2st
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11591653 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tropomyosin beta chain

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14937 TPM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18641 Tpm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25126 Tpm2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpm2 NCBI NCBI:7169