Tnr - tenascin R Gene

Mus musculus

Also known as TN-R; janusin; restrictin; J1-tenascin

Gene ID: 21960 | Gene type: protein coding

About Tnr

Summary

Predicted to enable Integrin binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including locomotory exploration behavior; modulation of chemical synaptic transmission; and nervous system development. Located in cell surface; membrane raft; and perineuronal net. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including aorta tunica media; brain; heart; urinary system; and ventral grey horn. Orthologous to human TNR (tenascin R). [provided by Alliance of Genome Resources, Apr 2022]

Tnr Products(1)

mRNA	Protein	Name
NM_022312.3	NP_071707.2	tenascin-R precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	12882316	MGI
acts upstream of axon extension	IDA IDA: Inferred from direct assay	16831557	MGI
acts upstream of axon extension involved in regeneration	IMP IMP: Inferred from mutant phenotype	16870730	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	10341229	MGI
acts upstream of or within locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	14529817	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	11161481	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	11377840	MGI
acts upstream of or within modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	11377840	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	11377840	MGI
acts upstream of or within negative regulation of axon extension	IDA IDA: Inferred from direct assay	16831557	MGI
acts upstream of or within negative regulation of axon extension involved in regeneration	IMP IMP: Inferred from mutant phenotype	16870730	MGI
acts upstream of or within negative regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	16831557	MGI
acts upstream of or within negative regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15034584	MGI
acts upstream of or within negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	9405406	MGI
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	7527058	MGI
acts upstream of or within negative regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	15033179	MGI
acts upstream of or within neuroblast migration	IMP IMP: Inferred from mutant phenotype	15034584	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	12882316	MGI
acts upstream of or within neuron cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15034584	MGI
acts upstream of or within positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11161481	MGI
acts upstream of or within positive regulation of transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	10341229	MGI
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	2477380	MGI
involved in regulation of cell differentiation	IDA IDA: Inferred from direct assay	9169525	MGI
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	2477380	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	16262627	MGI
acts upstream of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11161481	MGI
acts upstream of or within telencephalon cell migration	IMP IMP: Inferred from mutant phenotype	15034584	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11377840	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	11377840	MGI
located in cell surface	IDA IDA: Inferred from direct assay	12056833	MGI
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	8244531	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	7530142	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11377840	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11377840	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	12056833	MGI
located in perineuronal net	IDA IDA: Inferred from direct assay	8244531	MGI
part of tenascin complex	IPI IPI: Inferred from physical interaction	2477380	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tenascin-R

neural recognition molecule J1-160/180

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14862	TNR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18902	Tnr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25393	Tnr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnr	NCBI	NCBI:7143

Name
Email *

	Sorry, but the email address you supplied was invalid.