Tnfaip3 - tumor necrosis factor, alpha-induced protein 3 Gene

Mus musculus

Also known as A20; Tnfip3

Gene ID: 21929 | Gene type: protein coding

About Tnfaip3

Summary

Enables kinase binding activity and protein C-terminus binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within establishment of protein localization to vacuole; positive regulation of cellular protein catabolic process; and protein K63-linked deubiquitination. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; heart; and retina nuclear layer. Human ortholog(s) of this gene implicated in familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Tnfaip3 Products(2)

mRNA	Protein	Name
NM_001166402.1	NP_001159874.1	tumor necrosis factor alpha-induced protein 3 isoform 2
NM_009397.3	NP_033423.3	tumor necrosis factor alpha-induced protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IDA IDA: Inferred from direct assay	18342009	MGI
enables protein binding	IDA IDA: Inferred from direct assay	22733818	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10385526	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B-1 B cell homeostasis	IMP IMP: Inferred from mutant phenotype	21088135	MGI
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	23609450	MGI
acts upstream of or within establishment of protein localization to vacuole	IDA IDA: Inferred from direct assay	18952128	MGI
involved in negative regulation of B cell activation	IDA IDA: Inferred from direct assay	21088135	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	18342009	MGI
involved in negative regulation of chronic inflammatory response	IMP IMP: Inferred from mutant phenotype	18006655	MGI
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15962316	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11009421	MGI
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	23609450	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21088135	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	23609450	MGI
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18006655	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18006655	MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP IMP: Inferred from mutant phenotype	18342009	MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	18342009	MGI
involved in negative regulation of toll-like receptor 5 signaling pathway	IDA IDA: Inferred from direct assay	19912257	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21088135	MGI
involved in positive regulation of hepatocyte proliferation	IDA IDA: Inferred from direct assay	15962316	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	18952128	MGI
acts upstream of or within protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	24012418	MGI
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	18342009	MGI
involved in regulation of germinal center formation	IMP IMP: Inferred from mutant phenotype	21088135	MGI
involved in response to molecule of bacterial origin	IDA IDA: Inferred from direct assay	19912257	MGI
involved in response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	18342009	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10385526	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor alpha-induced protein 3

TNF alpha-induced protein 3	putative DNA-binding protein A20
tumor necrosis factor induced protein 3	zinc finger protein A20

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170863	ZSH-2208	Agonist	99.90%	Unkown
HY-RS14789	TNFAIP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17044	Tnfaip3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23488	Tnfaip3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfaip3	NCBI	NCBI:7128

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