2. Gene
  3. Timp3 - tissue inhibitor of metalloproteinase 3 Gene

Timp3 - tissue inhibitor of metalloproteinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Timp-3

Gene ID: 21859 | Gene type: protein coding

About Timp3

Summary

Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of metalloendopeptidase activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby's fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby's fundus dystrophy; breast carcinoma; and urinary bladder Cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]

Timp3 Products(1)

mRNA Protein Name
NM_011595.2 NP_035725.1 metalloproteinase inhibitor 3 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of metalloendopeptidase activity IMP
IMP: Inferred from mutant phenotype
24812324 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
12950084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloproteinase inhibitor 3

tissue inhibitor of metalloproteinases 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145426 MPT0B390 Inhibitor 98.76% Unkown
HY-RS14540 TIMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18302 Timp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24780 Timp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Timp3 NCBI NCBI:7078