Trim28 - tripartite motif-containing 28 Gene

Mus musculus

Also known as KAP-1; Tif1b; KRIP-1; MommeD9; Tif1beta

Gene ID: 21849 | Gene type: protein coding

About Trim28

Summary

Enables DNA binding activity; protein kinase activity; and transcription coactivator activity. Involved in epithelial to mesenchymal transition and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation involved in embryo development; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and regulation of nucleobase-containing compound metabolic process. Located in euchromatin; heterochromatin; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb primordium. Orthologous to human TRIM28 (tripartite motif containing 28). [provided by Alliance of Genome Resources, Apr 2022]

Trim28 Products(1)

mRNA	Protein	Name
NM_011588.3	NP_035718.2	transcription intermediary factor 1-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	22442485	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8978696	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	10562550	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11331592	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within convergent extension involved in axis elongation	IMP IMP: Inferred from mutant phenotype	22110054	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	22442485	MGI
acts upstream of or within embryonic placenta morphogenesis	IMP IMP: Inferred from mutant phenotype	22110054	MGI
acts upstream of or within epigenetic programming of gene expression	IMP IMP: Inferred from mutant phenotype	22442485	MGI
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	17273560	MGI
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	22442485	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	22442485	MGI
acts upstream of or within innate immune response	IDA IDA: Inferred from direct assay	19270682	MGI
acts upstream of or within innate immune response	IGI IGI: Inferred from genetic interaction	19270682	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10562550	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21518874	MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IDA IDA: Inferred from direct assay	19270682	MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IGI IGI: Inferred from genetic interaction	19270682	MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: Inferred from mutant phenotype	19270682	MGI
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: Inferred from mutant phenotype	20164836	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8986806	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22110054	MGI
acts upstream of or within positive regulation of DNA binding	IDA IDA: Inferred from direct assay	19270682	MGI
acts upstream of or within positive regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	19270682	MGI
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	20164836	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11331592	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17273560	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	10562550	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	10562550	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	17273560	MGI
located in chromatin	IDA IDA: Inferred from direct assay	11331580	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	10562550	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	10562550	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	10562550	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	10562550	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15469996	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription intermediary factor 1-beta

E3 SUMO-protein ligase TRIM28	KRAB-A-interacting protein
RING-type E3 ubiquitin transferase TIF1-beta	TIF1-beta
transcriptional intermediary factor 1, beta	tripartite motif protein 28
tripartite motif-containing protein 28

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15033	TRIM28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18012	Trim28 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24485	Trim28 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim28	NCBI	NCBI:10155

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