2. Gene
  3. Tie1 - tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Gene

Tie1 - tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TIE; tie-1; D430008P04Rik

Gene ID: 21846 | Gene type: protein coding

About Tie1

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Tie1 Products(1)

mRNA Protein Name
NM_011587.2 NP_035717.2 tyrosine-protein kinase receptor Tie-1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
31319059 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
23918385 MGI
involved in branching involved in lymph vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
20223757 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
11172728 MGI
acts upstream of or within lymphatic endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
20223757 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within plasma membrane fusion IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20223757 MGI
acts upstream of regulation of extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
31319059 MGI
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
18439490 MGI
involved in tissue remodeling IMP
IMP: Inferred from mutant phenotype
20223757 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17717145 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor Tie-1

tyrosine kinase receptor 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14520 TIE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15973 BSF-466895 Inhibitor / Unkown
HY-RS19390 Tie1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22860 Tial1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25882 Tie1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29374 Tial1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991384 DX-2240 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tie1 NCBI NCBI:7075