2. Gene
  3. Tial1 - Tia1 cytotoxic granule-associated RNA binding protein-like 1 Gene

Tial1 - Tia1 cytotoxic granule-associated RNA binding protein-like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TIAR; mTIAR; 5330433G13Rik

Gene ID: 21843 | Gene type: protein coding

About Tial1

Summary

Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within germ cell development; positive regulation of cell population proliferation; and stem cell division. Located in cytoplasmic stress granule and nucleus. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; and trunk. Orthologous to human TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]

Tial1 Products(3)

mRNA Protein Name
NM_001347640.1 NP_001334569.1 nucleolysin TIAR isoform 2
NM_001347641.1 NP_001334570.1 nucleolysin TIAR isoform 3
NM_009383.2 NP_033409.1 nucleolysin TIAR isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
10921895 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20477871 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within germ cell development IMP
IMP: Inferred from mutant phenotype
9482885 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9482885 MGI
acts upstream of or within stem cell division IMP
IMP: Inferred from mutant phenotype
9482885 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9482885 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16278295 MGI
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
19825938 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9482885 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolysin TIAR

TIA-1-related protein

Tial1 cytotoxic granule-associated RNA binding protein-like 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14514 TIAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14520 TIE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15973 BSF-466895 Inhibitor / Unkown
HY-RS19390 Tie1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22860 Tial1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25882 Tie1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29374 Tial1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991384 DX-2240 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tial1 NCBI NCBI:7073