2. Gene
  3. Thrb - thyroid hormone receptor beta Gene

Thrb - thyroid hormone receptor beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta

Gene ID: 21834 | Gene type: protein coding

About Thrb

Summary

Enables chromatin DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including female mating behavior; regulation of transcription by RNA polymerase II; and retinal cone cell apoptotic process. Located in nucleus. Is expressed in several structures, including brown fat; endocrine gland; liver; sensory organ; and vestibulo-cochlear ganglion. Used to study attention deficit hyperactivity disorder; thyroid gland follicular carcinoma; and thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (Thyroid Hormone Receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Thrb Products(2)

mRNA Protein Name
NM_001113417.1 NP_001106888.1 thyroid hormone receptor beta isoform 1
NM_009380.3 NP_033406.1 thyroid hormone receptor beta isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
17952069 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22079090 MGI
enables nuclear receptor activity IMP
IMP: Inferred from mutant phenotype
20203194 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9405624 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
9927422 MGI
acts upstream of or within female courtship behavior IMP
IMP: Inferred from mutant phenotype
10769387 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15062575 MGI
acts upstream of or within negative regulation of female receptivity IMP
IMP: Inferred from mutant phenotype
10769387 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
7566114 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
12407160 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
9832432 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19052228 MGI
acts upstream of or within retinal cone cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20203194 MGI
acts upstream of retinal cone cell development IMP
IMP: Inferred from mutant phenotype
20203194 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
8673137 MGI
acts upstream of or within type I pneumocyte differentiation IGI
IGI: Inferred from genetic interaction
22001906 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
17952069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyroid hormone receptor beta

TR beta

c-erbA-2

c-erbA-beta

nuclear receptor subfamily 1 group A member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14501 THRB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-171815 THRB-4 siRNA Pre-designed Set / Unkown
HY-RS20346 Thrb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26855 Thrb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thrb NCBI NCBI:7068