Tgfb3 - transforming growth factor, beta 3 Gene

Mus musculus

Also known as Tgfb-3; TGF-beta-3

Gene ID: 21809 | Gene type: protein coding

About Tgfb3

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Homozygous knockout mice for this gene exhibit cleft palate, delayed pulmonary development and neonatal death. [provided by RefSeq, Aug 2016]

Tgfb3 Products(1)

mRNA	Protein	Name
NM_009368.3	NP_033394.2	transforming growth factor beta-3 proprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28912269	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	14697364	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	12815624	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	14729481	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	12815624	MGI
involved in face morphogenesis	IEP IEP: Inferred from expression pattern	18498113	MGI
acts upstream of filopodium assembly	IMP IMP: Inferred from mutant phenotype	16806156	MGI
acts upstream of or within positive effect gene expression	IMP IMP: Inferred from mutant phenotype	16245336	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	14729481	MGI
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	7493022	MGI
acts upstream of or within mammary gland development	IDA IDA: Inferred from direct assay	1821856	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	12815624	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17159989	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17159989	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14691138	MGI
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16806156	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	16806156	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	21984612	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17159989	MGI
NOT involved in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19161227	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	16245336	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	7493021	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14691138	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	10521784	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transforming growth factor beta-3 proprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14442	TGFB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16996	Tgfb3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23439	Tgfb3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb3	NCBI	NCBI:7043
Rattus norvegicus	Tgfb3	NCBI	NCBI:25717

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