Nlgn2 - neuroligin 2 Gene

Mus musculus

Also known as NL2; NLG2

Gene ID: 216856 | Gene type: protein coding

About Nlgn2

Summary

Enables cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of signal transduction; and synapse organization. Acts upstream of or within several processes, including GABAergic synaptic transmission; protein localization to cell surface; and regulation of respiratory gaseous exchange by nervous system process. Located in GABA-ergic synapse; cell surface; and dopaminergic synapse. Is active in glycinergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in brainstem. Used to study schizophrenia. Orthologous to human NLGN2 (neuroligin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn2 Products(2)

mRNA	Protein	Name
NM_001364137.1	NP_001351066.1	neuroligin-2 precursor
NM_198862.2	NP_942562.2	neuroligin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	21424692	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	18250328	MGI
enables neurexin family protein binding	IPI IPI: Inferred from physical interaction	21424692	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19816407	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in gephyrin clustering involved in postsynaptic density assembly	IDA IDA: Inferred from direct assay	15620359	MGI
acts upstream of or within gephyrin clustering involved in postsynaptic density assembly	IGI IGI: Inferred from genetic interaction	29107521	MGI
acts upstream of or within gephyrin clustering involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	29107521	MGI
involved in inhibitory synapse assembly	IDA IDA: Inferred from direct assay	22960622	MGI
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	19016888	MGI
acts upstream of or within modulation of chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	16982420	MGI
involved in neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	19016888	MGI
acts upstream of or within neurotransmitter-gated ion channel clustering	IDA IDA: Inferred from direct assay	29107521	MGI
acts upstream of or within neurotransmitter-gated ion channel clustering	IGI IGI: Inferred from genetic interaction	29107521	MGI
acts upstream of or within neurotransmitter-gated ion channel clustering	IMP IMP: Inferred from mutant phenotype	29107521	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15620359	MGI
involved in positive regulation of inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15620359	MGI
involved in positive regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	15620359	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	15620359	MGI
involved in positive regulation of synaptic vesicle clustering	IDA IDA: Inferred from direct assay	15620359	MGI
involved in postsynaptic density protein 95 clustering	IDA IDA: Inferred from direct assay	15620359	MGI
involved in postsynaptic membrane assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in postsynaptic specialization assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in postsynaptic specialization assembly	IMP IMP: Inferred from mutant phenotype	15620359	MGI
acts upstream of or within presynapse assembly	IDA IDA: Inferred from direct assay	23358245	MGI
involved in presynaptic membrane assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in presynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	19016888	MGI
acts upstream of or within protein localization to cell surface	IDA IDA: Inferred from direct assay	29107521	MGI
acts upstream of or within protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	29107521	MGI
involved in protein localization to synapse	IDA IDA: Inferred from direct assay	15620359	MGI
involved in regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	15620359	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IGI IGI: Inferred from genetic interaction	16982420	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	19016888	MGI
acts upstream of or within synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	29107521	MGI
acts upstream of or within synaptic transmission, GABAergic	IGI IGI: Inferred from genetic interaction	29107521	MGI
acts upstream of or within synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	29107521	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15620359	MGI
located in GABA-ergic synapse	IDA IDA: Inferred from direct assay	29107521	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	15620359	MGI
is active in axon	IDA IDA: Inferred from direct assay	23358245	MGI
is active in cell surface	IDA IDA: Inferred from direct assay	23358245	MGI
located in cell surface	IDA IDA: Inferred from direct assay	29107521	MGI
is active in dendrite	IDA IDA: Inferred from direct assay	23358245	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	27035941	MGI
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	19755106	MGI
is active in glycinergic synapse	IMP IMP: Inferred from mutant phenotype	19755106	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	27035941	MGI
located in synapse	IDA IDA: Inferred from direct assay	15681343	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuroligin-2

ortholog of human and rat neuroligin 2 NLGN2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09340	NLGN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22679	Nlgn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29193	Nlgn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlgn2	NCBI	NCBI:57555

Name
Email *

	Sorry, but the email address you supplied was invalid.