Kmt2a - lysine (K)-specific methyltransferase 2A Gene

Mus musculus

Also known as HRX; Mll; All1; Mll1; ALL-1; Cxxc7; HTRX1; mKIAA4050; 6430520K01

Gene ID: 214162 | Gene type: protein coding

About Kmt2a

Summary

Enables DNA binding activity; chromatin binding activity; and Histone Methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2a Products(1)

mRNA	Protein	Name
NM_001357549.2	NP_001344478.1	histone-lysine N-methyltransferase 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	24824656	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15640349	MGI
enables histone H3K4 methyltransferase activity	IDA IDA: Inferred from direct assay	12453418	MGI
enables histone H3K4 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	16618927	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16618927	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	15741318	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	16618927	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21113167	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	25834037	MGI
involved in definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	15556871	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	9639506	MGI
acts upstream of or within epigenetic regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16618927	MGI
acts upstream of or within exploration behavior	IMP IMP: Inferred from mutant phenotype	25834037	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15640349	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	22674806	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15640349	MGI
acts upstream of or within peptidyl-lysine monomethylation	IMP IMP: Inferred from mutant phenotype	25834037	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21113167	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15640349	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12453418	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	22674806	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25834037	MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	25834037	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	25834037	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	22674806	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	25834037	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11555636	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase 2A

cysteine methyltransferase KMT2A	histone-lysine N-methyltransferase MLL
myeloid/lymphoid or mixed-lineage leukemia protein 1	trithorax Drosophila
zinc finger protein HRX

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148669	Bleximenib		99.36%	Phase 2
HY-148669A	Bleximenib oxalate		98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148669B	(S)-Bleximenib oxalate	Control	98.37%	Unkown
HY-170832	Menin–KMT2A-IN-1	Inhibitor	/	Unkown
HY-RS07401	KMT2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18528	Kmt2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25010	Kmt2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kmt2a	NCBI	NCBI:4297

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