Ago3 - argonaute RISC catalytic subunit 3 Gene

Mus musculus

Also known as Eif2c3; C130014L07Rik

Gene ID: 214150 | Gene type: protein coding

About Ago3

Summary

Enables RNA binding activity. Involved in positive regulation of NIK/NF-kappaB signaling and positive regulation of gene expression. Located in condensed nuclear chromosome. Part of RISC complex. Is expressed in several structures, including central nervous system; early embryo; lung mesenchyme; sensory organ; and tooth. Orthologous to human AGO3 (argonaute RISC catalytic component 3). [provided by Alliance of Genome Resources, Apr 2022]

Ago3 Products(1)

mRNA	Protein	Name
NM_153402.2	NP_700451.2	protein argonaute-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19536157	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26764146	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	26764146	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RISC complex	IDA IDA: Inferred from direct assay	19536157	MGI
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	22863743	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein argonaute-3

Piwi/Argonaute family protein meIF2C3	argonaute 3
argonaute RISC catalytic component 3	argonaute3
eIF-2C 3	eIF2C 3
eukaryotic translation initiation factor 2C, 3	mAgo3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00454	AGO3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20689	Ago3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ago3	NCBI	NCBI:192669

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