Tcf7 - transcription factor 7, T cell specific Gene

Mus musculus

Also known as Tcf1; TCF-1

Gene ID: 21414 | Gene type: protein coding

About Tcf7

Summary

This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Tcf7 Products(2)

mRNA	Protein	Name
NM_001313981.1	NP_001300910.1	transcription factor 7
NM_009331.4	NP_033357.1	transcription factor 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1827138	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12235125	MGI
enables DNA-binding transcription repressor activity	IMP IMP: Inferred from mutant phenotype	17218525	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22723415	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22723415	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17218525	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell receptor V(D)J recombination	IGI IGI: Inferred from genetic interaction	9462507	MGI
acts upstream of or within alpha-beta T cell differentiation	IGI IGI: Inferred from genetic interaction	9462507	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	12235125	MGI
involved in canonical Wnt signaling pathway involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12235125	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IGI IGI: Inferred from genetic interaction	15057272	MGI
acts upstream of or within embryonic genitalia morphogenesis	IGI IGI: Inferred from genetic interaction	15057272	MGI
acts upstream of or within embryonic hindgut morphogenesis	IGI IGI: Inferred from genetic interaction	15057272	MGI
involved in gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	30413363	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12235125	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22723415	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	15057272	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23562159	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12235125	MGI
involved in regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	23562159	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12235125	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in euchromatin	IDA IDA: Inferred from direct assay	22723415	MGI
located in nucleus	IDA IDA: Inferred from direct assay	1827138	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor 7

T-cell-specific transcription factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14308	TCF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14309	TCF7L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14310	TCF7L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17858	Tcf7l2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20345	Tcf7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24327	Tcf7l2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26854	Tcf7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf7	NCBI	NCBI:6932

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