Slc18a2 - solute carrier family 18 (vesicular monoamine), member 2 Gene

Mus musculus

Also known as Vmat2; 9330105E13; 1110037L13Rik

Gene ID: 214084 | Gene type: protein coding

About Slc18a2

Summary

Predicted to enable several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and serotonin:sodium symporter activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within several processes, including locomotory behavior; response to amphetamine; and response to toxic substance. Located in dopaminergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; eye; integumental system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a2 Products(1)

mRNA	Protein	Name
NM_172523.3	NP_766111.1	synaptic vesicular amine transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19357284	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	10618388	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	9275230	MGI
involved in neurotransmitter loading into synaptic vesicle	IDA IDA: Inferred from direct assay	9427251	MGI
involved in neurotransmitter loading into synaptic vesicle	IMP IMP: Inferred from mutant phenotype	9427251	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	9275230	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	9275230	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	9275230	MGI
involved in serotonin secretion by mast cell	IMP IMP: Inferred from mutant phenotype	10618388	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	9427251	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	9427251	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	9427251	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptic vesicular amine transporter

VAT2	monoamine transporter
solute carrier family 18 member 2	vesicular amine transporter 2
vesicular monoamine transporter 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13044	SLC18A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22032	Slc18a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc18a2	NCBI	NCBI:6571

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