Tbx5 - T-box 5 Gene

Mus musculus

Gene ID: 21388 | Gene type: protein coding

About Tbx5

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in heart development; positive regulation of gap junction assembly; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell communication involved in cardiac conduction; heart development; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; eye; genitourinary system; heart; and vena cava. Used to study Holt-Oram syndrome. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Tbx5 Products(1)

mRNA	Protein	Name
NM_011537.3	NP_035667.1	T-box transcription factor TBX5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11555635	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22728936	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11555635	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22728936	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14550786	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11572777	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within atrial septum development	IMP IMP: Inferred from mutant phenotype	19084512	MGI
acts upstream of or within atrial septum morphogenesis	IGI IGI: Inferred from genetic interaction	22898775	MGI
involved in atrioventricular bundle cell differentiation	IMP IMP: Inferred from mutant phenotype	15289437	MGI
involved in atrioventricular node cell development	IMP IMP: Inferred from mutant phenotype	15289437	MGI
involved in atrioventricular node cell fate commitment	IMP IMP: Inferred from mutant phenotype	15289437	MGI
acts upstream of or within atrioventricular valve morphogenesis	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of positive effect bundle of His cell to Purkinje myocyte communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	22728936	MGI
acts upstream of or within bundle of His development	IGI IGI: Inferred from genetic interaction	17604724	MGI
involved in bundle of His development	IMP IMP: Inferred from mutant phenotype	22728936	MGI
involved in cardiac left ventricle formation	IMP IMP: Inferred from mutant phenotype	19727199	MGI
acts upstream of or within cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	20691899	MGI
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	11431700	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of positive effect cell-cell signaling	IGI IGI: Inferred from genetic interaction	22728936	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	11572777	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	16380715	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	12736217	MGI
acts upstream of or within endocardial cushion development	IGI IGI: Inferred from genetic interaction	19084512	MGI
acts upstream of or within forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	15621531	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	11572777	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12508227	MGI
acts upstream of or within morphogenesis of an epithelium	IMP IMP: Inferred from mutant phenotype	12508227	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	15289437	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11555635	MGI
acts upstream of positive regulation of cardiac conduction	IMP IMP: Inferred from mutant phenotype	22728936	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	19084512	MGI
involved in positive regulation of gap junction assembly	IMP IMP: Inferred from mutant phenotype	22728936	MGI
acts upstream of or within positive regulation of secondary heart field cardioblast proliferation	IMP IMP: Inferred from mutant phenotype	22898775	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22728936	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16380715	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24565863	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16870172	MGI
acts upstream of positive effect regulation of atrial cardiac muscle cell membrane depolarization	IGI IGI: Inferred from genetic interaction	22728936	MGI
involved in sinoatrial node development	IMP IMP: Inferred from mutant phenotype	11572777	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17604724	MGI
acts upstream of or within ventricular cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	19084512	MGI
involved in ventricular septum development	IMP IMP: Inferred from mutant phenotype	19727199	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11572777	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	18285513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-box transcription factor TBX5

T-box protein 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14281	TBX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21440	Tbx5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx5	NCBI	NCBI:6910

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