2. Gene
  3. Tapbp - TAP binding protein Gene

Tapbp - TAP binding protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TPN; D17Wsu91e

Gene ID: 21356 | Gene type: protein coding

About Tapbp

Summary

Predicted to enable TAP complex binding activity; TAP1 binding activity; and TAP2 binding activity. Involved in peptide antigen stabilization. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent and defense response. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of MHC class I peptide loading complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; notochord; and retina. Human ortholog(s) of this gene implicated in MHC class I deficiency and severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tapbp Products(2)

mRNA Protein Name
NM_001025313.1 NP_001020484.1 tapasin isoform 1 precursor
NM_009318.2 NP_033344.1 tapasin isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15187134 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent IDA
IDA: Inferred from direct assay
9716645 MGI
involved in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent IDA
IDA: Inferred from direct assay
9716645 MGI
acts upstream of or within defense response IMP
IMP: Inferred from mutant phenotype
10981964 MGI
involved in peptide antigen stabilization IMP
IMP: Inferred from mutant phenotype
12594855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tapasin

TAP-associated protein

TPSN

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14203 TAPBP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18686 Tapbp Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25172 Tapbp Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tapbp NCBI NCBI:6892
Macaca mulatta Tapbp NCBI NCBI:718235