Tal1 - T cell acute lymphocytic leukemia 1 Gene

Mus musculus

Also known as Hpt; Scl; tal-1; bHLHa17; SCL/tal-1

Gene ID: 21349 | Gene type: protein coding

About Tal1

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]

Tal1 Products(2)

mRNA	Protein	Name
NM_001287388.1	NP_001274317.1	T-cell acute lymphocytic leukemia protein 1 homolog
NM_011527.3	NP_035657.1	T-cell acute lymphocytic leukemia protein 1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	9391090	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	22835905	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18550854	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	18550854	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17962413	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18184866	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9391090	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9111058	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	9472016	MGI
acts upstream of or within astrocyte fate commitment	IMP IMP: Inferred from mutant phenotype	16292311	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12569129	MGI
acts upstream of or within central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	16292311	MGI
acts upstream of or within definitive hemopoiesis	IMP IMP: Inferred from mutant phenotype	8861941	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	7624372	MGI
involved in embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	19200805	MGI
acts upstream of or within erythrocyte differentiation	IDA IDA: Inferred from direct assay	11731461	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	11731461	MGI
acts upstream of or within erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	18550854	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	16623824	MGI
acts upstream of or within hemangioblast cell differentiation	IMP IMP: Inferred from mutant phenotype	15677567	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	14726374	MGI
acts upstream of or within hemopoiesis	IDA IDA: Inferred from direct assay	12485991	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	16623824	MGI
acts upstream of or within megakaryocyte development	IMP IMP: Inferred from mutant phenotype	16763211	MGI
acts upstream of or within megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	12552125	MGI
acts upstream of or within myeloid cell differentiation	IDA IDA: Inferred from direct assay	14726394	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	12552125	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8760303	MGI
acts upstream of or within platelet formation	IMP IMP: Inferred from mutant phenotype	16763211	MGI
involved in positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	19497860	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9819382	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20194619	MGI
acts upstream of or within regulation of mast cell differentiation	IMP IMP: Inferred from mutant phenotype	17644741	MGI
acts upstream of or within regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	16763211	MGI
acts upstream of or within regulation of somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19850742	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19497860	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	19323994	MGI
acts upstream of positive effect transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16673016	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9391090	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	9391090	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	8760303	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	15314159	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-cell acute lymphocytic leukemia protein 1 homolog

stem cell protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136522	S2116		98.05%	Unkown
HY-136523	S2157		98.44%	Unkown
HY-RS14189	TAL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17898	Tal1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24367	Tal1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tal1	NCBI	NCBI:6886

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