Slc39a14 - solute carrier family 39 (zinc transporter), member 14 Gene

Mus musculus

Also known as Zip14; ZIP-14; fad123; FAD-123

Gene ID: 213053 | Gene type: protein coding

About Slc39a14

Summary

Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including negative regulation of cyclic-nucleotide phosphodiesterase activity; transition metal ion homeostasis; and transition metal ion transport. Acts upstream of or within iron ion transport and zinc ion transport. Located in basolateral plasma membrane. Is expressed in autopod; ear; face; nervous system; and skeleton. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Apr 2022]

Slc39a14 Products(3)

mRNA	Protein	Name
NM_001135151.1	NP_001128623.1	metal cation symporter ZIP14 isoform a precursor
NM_001135152.1	NP_001128624.1	metal cation symporter ZIP14 isoform a precursor
NM_144808.4	NP_659057.2	metal cation symporter ZIP14 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadmium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18270315	MGI
enables ferrous iron transmembrane transporter activity	IDA IDA: Inferred from direct assay	16950869	MGI
enables iron ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	21653899	MGI
enables manganese ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18270315	MGI
enables monoatomic anion:monoatomic cation symporter activity	IDA IDA: Inferred from direct assay	18270315	MGI
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	16950869	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	27703010	MGI
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	27703010	MGI
acts upstream of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	21445361	MGI
acts upstream of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	21445361	MGI
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	18270315	MGI
acts upstream of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27703010	MGI
involved in intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	21445361	MGI
involved in iron import into cell	IMP IMP: Inferred from mutant phenotype	20682781	MGI
involved in iron ion transmembrane transport	IDA IDA: Inferred from direct assay	21653899	MGI
involved in iron ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	20682781	MGI
acts upstream of or within iron ion transport	IDA IDA: Inferred from direct assay	16950869	MGI
involved in manganese ion homeostasis	IMP IMP: Inferred from mutant phenotype	28536273	MGI
involved in manganese ion transmembrane transport	IDA IDA: Inferred from direct assay	18270315	MGI
involved in positive regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21445361	MGI
acts upstream of regulation of hormone levels	IMP IMP: Inferred from mutant phenotype	21445361	MGI
involved in zinc ion transmembrane transport	IDA IDA: Inferred from direct assay	21653899	MGI
acts upstream of or within zinc ion transport	IDA IDA: Inferred from direct assay	16950869	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	28536273	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16950869	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metal cation symporter ZIP14

Zrt- and Irt-like protein 14	factor for adipocyte differentiation 123
zinc transporter ZIP14

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13233	SLC39A14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20674	Slc39a14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27185	Slc39a14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc39a14	NCBI	NCBI:23516

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